Last update :
19/11/2024
Antiepileptic   Valproic acid  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Acido valproico Spain
Convulex Iran
Depacon United States of America
Depakene Mexico
Depakin Italy
Depakine Belgium, Greece, Hungary, Iran, Luxembourg, Netherlands, Poland, Portugal, Saudi Arabia, Spain, Switzerland, United Arab Emirates
Depalept Egypt
Deprakine Finland
Diplexil Portugal
Epilim Great Britain, Ireland, Malaysia, New Zealand
Episenta Great Britain
Ergenyl Germany, Sweden
Milzone Spain
Orfiril Denmark, Finland, Germany, Iran, Ireland, Netherlands, Norway, Sweden, Switzerland
Orlept Iran
Valcote Argentina, Chile, Colombia, Venezuela
Valprax Peru
Valproate Mylan Belgium
Valproate sodium United States of America
Compatibility   injection   Compatibility : Valproic acid              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
injection Valproic acid 2 & 20 mg/ml
injection Atracurium besylate 0.2 mg/ml
NaCl 0,9% or Glucose 5% 4428
Compatible
injection Valproic acid 100 mg/ml
injection Cefepime dihydrochloride 125 mg/ml
Water for Injection 2141
Compatible
injection Valproic acid 100 mg/ml
injection Ceftazidime 125 mg/ml
Water for Injection 2141
Compatible
injection Valproic acid 100 mg/ml
injection Ceftazidime 83.3 mg/ml
1759
Compatible
injection Valproic acid 16 mg/ml
injection Clonazepam 0.2 mg/ml
Sodium chloride 0,9% 3823
Compatible
injection Valproic acid 16 mg/ml
injection Clonidine hydrochloride 0.012 mg/ml
Sodium chloride 0,9% 3823
Compatible
injection Valproic acid 100 mg/ml
injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Compatible
injection Valproic acid 2 & 20 mg/ml
injection Dexamethasone sodium phosphate 0.64 mg/ml
NaCl 0,9% or Glucose 5% 4428
Compatible
injection Valproic acid 100 mg/ml
injection Dexmedetomidine 100 µg/ml
4389
Immediate precipitation Incompatible
injection Valproic acid 2 & 20 mg/ml
injection Diazepam 5 mg/ml
NaCl 0,9% or Glucose 5% 4428
Compatible
injection Valproic acid 10 mg/ml
injection Dobutamine hydrochloride 2 mg/ml
Glucose 5% 3942
Compatible
injection Valproic acid 10 mg/ml
injection Dopamine hydrochloride 1,6 mg/ml
Glucose 5% 3942
Compatible
injection Valproic acid 2 & 20 mg/ml
injection Fosphenytoin sodium
NaCl 0,9% or Glucose 5% 4428
Unspecified incompatibility Incompatible
injection Valproic acid 16 mg/ml
injection Haloperidol lactate 0,5 mg/ml
Sodium chloride 0,9% 3823
Compatible
injection Valproic acid 50 mg/ml
injection Insulin aspart 1 UI/ml
NaCl 0,9% or Glucose 5% 1508
Compatible
injection Valproic acid 2 & 20 mg/ml
injection Lorazepam 1 mg/ml
NaCl 0,9% or Glucose 5% 4428
Compatible
injection Valproic acid 2 & 20 mg/ml
injection Magnesium sulfate 100 mg/ml
NaCl 0,9% or Glucose 5% 4428
Compatible
injection Valproic acid 16 mg/ml
injection Mannitol 200 mg/ml
Sodium chloride 0,9% 3823
Compatible
injection Valproic acid 2 & 20 mg/ml
injection Mannitol 150 mg/ml
NaCl 0,9% or Glucose 5% 4428
Compatible
injection Valproic acid 100 mg/ml
injection Meropenem 50 mg/ml
Water for Injection 4319
Compatible
injection Valproic acid 2 & 20 mg/ml
injection Methylprednisolone sodium succinate 5 mg/ml
NaCl 0,9% or Glucose 5% 4428
Unspecified incompatibility Incompatible
injection Valproic acid 16 mg/ml
injection Midazolam hydrochloride 2,1 mg/ml
Sodium chloride 0,9% 3823
Immediate precipitation Incompatible
injection Valproic acid 2 & 20 mg/ml
injection Midazolam hydrochloride 2 mg/ml
NaCl 0,9% or Glucose 5% 4428
Compatible
injection Valproic acid 100 mg/ml
injection Naloxone hydrochloride 0.4 mg/ml
None 3408
Unspecified incompatibility Incompatible
injection Valproic acid 16 mg/ml
injection Nimodipine 0,2 mg/ml
Sodium chloride 0,9% 3823
Compatible
injection Valproic acid 2 & 20 mg/ml
injection Pentobarbital sodium 5 mg/ml
NaCl 0,9% or Glucose 5% 4428
Immediate precipitation Incompatible
injection Valproic acid 2 & 20 mg/ml
injection Phenytoin sodium 50 mg/ml
NaCl 0,9% or Glucose 5% 4428
Compatible
injection Valproic acid 2 & 20 mg/ml
injection Ranitidine hydrochloride 25 mg/ml
NaCl 0,9% or Glucose 5% 4428
Compatible
injection Valproic acid 100 mg/ml
injection Temocilline 83.33 mg/ml
Water for Injection 2231
Compatible
injection Valproic acid 2 & 20 mg/ml
injection Thiopental sodium 25 mg/ml
NaCl 0,9% or Glucose 5% 4428
Compatible
injection Valproic acid 16 mg/ml
injection Thiopental sodium 60 mg/ml
Sodium chloride 0,9% 3823
Unspecified incompatibility Incompatible
injection Valproic acid 100 mg/ml
injection Vancomycin hydrochloride 10 mg/ml
Glucose 5% 3385

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