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References   References 929  
Type : Journal
Web link : https://www.sciencedirect.com/science/article/pii/S0885392498000244
Research teams : Callaghan - School of Pharmacy and Medical Sciences
Authors : Wilson KM, Schneider JJ, Ravenscroft PJ.
Title : Stability of midazolam and fentanyl in infusion solutions.
Reference : J Pain Symptom Manage ; 16: 52-58. 1998
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement Water loss by evaporation 
Comments : 
List of drugs
injectionFentanyl citrate Analgesic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 13 & 34 µg/ml 22°C Not specified
7 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 13 & 34 µg/ml 38°C Not specified
7 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 13 & 34 µg/ml 5°C Protect from light
7 Day
Compatible 13 & 38 µg/ml + injectionMidazolam hydrochloride 0,66 & 0,9 mg/ml + Sodium chloride 0,9%
injectionMidazolam hydrochloride Anxiolytic
Compatible 0,66 & 0,9 mg/ml + injectionFentanyl citrate 13 & 38 µg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 22°C Not specified
injection Midazolam hydrochloride 0,66 & 0,9 mg/ml
injection Fentanyl citrate 13 & 38 µg/ml
7 Day
Polypropylen Syringe Sodium chloride 0,9% 38°C Not specified
injection Midazolam hydrochloride 0,66 & 0,9 mg/ml
injection Fentanyl citrate 13 & 38 µg/ml
4 Day
Polypropylen Syringe Sodium chloride 0,9% 5°C Protect from light
injection Midazolam hydrochloride 0,66 & 0,9 mg/ml
injection Fentanyl citrate 13 & 38 µg/ml
7 Day
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