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References   References 86  
Type : Journal
Research teams : Ann Arbor - University of Michigan, College of Pharmacy
Authors : Johnson CE, Bhatt-Mehta V, Mancari SC, McKown JA.
Title : Stability of midazolam hydrochloride and morphine sulfate during simulated intravenous coadministration.
Reference : Am J Hosp Pharm ; 51: 2812-2815. 1994
Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
List of drugs
injectionMidazolam hydrochloride Anxiolytic
Compatible 0,1 & 0,5 mg/ml + injectionMorphine sulfate 0,25 & 1 mg/ml + Glucose 5%
injectionMorphine sulfate Analgesic
Compatible 0,25 & 1 mg/ml + injectionMidazolam hydrochloride 0,1 & 0,5 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 23°C-25°C Light
injection Morphine sulfate 0,25 & 1 mg/ml
injection Midazolam hydrochloride 0,1 & 0,5 mg/ml
3 Hour
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