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References   References 612  
Type : Journal
Research teams : Indianapolis - Eli Lilly and Company, Lilly Research Laboratories
Authors : Frable RA, Klink PR, Engel GL, Mundell EE.
Title : Stability of cefamandole nafate injection with parenteral solutions and additives.
Reference : Am J Hosp Pharm ; 39: 622-627. 1982
Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionCalcium gluconate Electrolyte
Incompatible + injectionCefamandole nafate 2 >> 100 mg/ml + NaCl 0,9% or Glucose 5%
injectionCefamandole nafate Antibiotic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 2 & 20 mg/ml 25°C Not specified
72 Hour
Stability in solutions Glass NaCl 0,9% or Glucose 5% 2 & 20 mg/ml 5°C Protect from light
7 Day
Stability in solutions Glass Sodium chloride 0,9% 285 mg/ml 25°C Not specified
72 Hour
Stability in solutions Glass Sodium chloride 0,9% 285 mg/ml 5°C Protect from light
10 Day
Stability in solutions Glass Water for injection + antibacterial 285 mg/ml 25°C Not specified
72 Hour
Stability in solutions Glass Water for injection + antibacterial 285 mg/ml 5°C Protect from light
10 Day
Stability in solutions Glass NaCl 0,9% + antibacterial 285 mg/ml 25°C Not specified
72 Hour
Stability in solutions Glass NaCl 0,9% + antibacterial 285 mg/ml 5°C Protect from light
10 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Not specified
72 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 20 mg/ml 5°C Protect from light
7 Day
Incompatible 2 >> 100 mg/ml + injectionCalcium gluconate + NaCl 0,9% or Glucose 5%
Incompatible 2 >> 100 mg/ml + injectionGentamicin sulfate + NaCl 0,9% or Glucose 5%
Compatible 285 mg/ml + injectionLidocaine hydrochloride 5 >> 20 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 2 >> 100 mg/ml + injectionTobramycin sulfate + NaCl 0,9% or Glucose 5%
Incompatible 2 mg/ml + Ringer’s lactate solution
injectionGentamicin sulfate Antibiotic
Incompatible + injectionCefamandole nafate 2 >> 100 mg/ml + NaCl 0,9% or Glucose 5%
injectionLidocaine hydrochloride Local anesthetic
Compatible 5 >> 20 mg/ml + injectionCefamandole nafate 285 mg/ml + NaCl 0,9% or Glucose 5%
injectionTobramycin sulfate Antibiotic
Incompatible + injectionCefamandole nafate 2 >> 100 mg/ml + NaCl 0,9% or Glucose 5%
  Mentions Légales