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References   References 513  
Type : Journal
Web link : https://doi.org/10.1177/106002809603000709
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Xu QA, Trissel LA, Martinez JF.
Title : Stability and compatibility of fluorouracil with morphine sulfate and hydromorphone hydrochloride.
Reference : Ann Pharmacotherapy ; 30: 756-761. 1996
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Degradation products not observed in real conditions
List of drugs
InjectionFluorouracil Anticancer drug
Compatible 1 & 16 mg/ml + InjectionHydromorphone hydrochloride 0.5 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 & 16 mg/ml + InjectionMorphine sulfate 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + InjectionFluorouracil 1 & 16 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMorphine sulfate Analgesic
Incompatible 1 mg/ml + InjectionFluorouracil 1 & 16 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% -20°C Protect from light
Injection Fluorouracil 1 & 16 mg/ml
Injection Hydromorphone hydrochloride 0,5 mg/ml
35 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 23°C Not specified
Injection Fluorouracil 16 mg/ml
Injection Hydromorphone hydrochloride 0,5 mg/ml
7 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 23°C Not specified
Injection Fluorouracil 1 mg/ml
Injection Hydromorphone hydrochloride 0,5 mg/ml
35 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 32°C Not specified
Injection Fluorouracil 16 mg/ml
Injection Hydromorphone hydrochloride 0,5 mg/ml
3 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 32°C Not specified
Injection Fluorouracil 1 mg/ml
Injection Hydromorphone hydrochloride 0,5 mg/ml
7 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
Injection Fluorouracil 1 & 16 mg/ml
Injection Hydromorphone hydrochloride 0,5 mg/ml
35 Day
  Mentions Légales