Bibliographie - 5102 - Stabilis 4.0

Last update :
03/03/2026

References 5102

Type :

Journal

Web link :

https://pubmed.ncbi.nlm.nih.gov/38290833/

Research teams :

Lille - Faculté des Sciences Pharmaceutiques et Biologiques

Authors :

Roche M, Rousseleau D, Danel C, Henry H, Lebuffe G, Odou P, Lannoy D, Simon N.

Title :

Combination of a propofol emulsion with alpha-2 adrenergic receptor agonists used for multimodal analgesia or sedation in intensive care units: a physicochemical stability study

Reference :

EJHP 2025;32:461–467. 2025

Level of Evidence :

Physical stability :

Chemical stability :

High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)

Stability defined as 90% of the initial concentration

Other methods :

Comments :

List of drugs

Clonidine hydrochloride

Propofol

Dexmedetomidine

Propofol

		+ Clonidine hydrochloride		+
		+ Dexmedetomidine		+

25°C

Clonidine hydrochloride	0,010 mg/ml
Propofol	10,59 mg/ml

25°C

Propofol	16,36 mg/ml
Clonidine hydrochloride	0,004 mg/ml

25°C

Clonidine hydrochloride	0,016 mg/ml
Propofol	5,45 mg/ml

25°C

Clonidine hydrochloride	0,009 mg/ml
Propofol	12 mg/ml

25°C

Clonidine hydrochloride	0,015 mg/ml
Propofol	15,79 mg/ml

25°C

Propofol	18,75 mg/ml
Clonidine hydrochloride	0,004 mg/ml

25°C

Clonidine hydrochloride	0,033 mg/ml
Propofol	11,11 mg/ml

25°C

Clonidine hydrochloride	0,012 mg/ml
Propofol	16,67 mg/ml

25°C

Propofol	10,59 mg/ml
Dexmedetomidine	4,24 µg/ml

25°C

Propofol	16,36 mg/ml
Dexmedetomidine	1,64 µg/ml

25°C

Propofol	4,86 mg/ml
Dexmedetomidine	6,81 µg/ml

25°C

Propofol	11,25 mg/ml
Dexmedetomidine	3,94 µg/ml

25°C

Propofol	15,79 mg/ml
Dexmedetomidine	6,32 µg/ml

25°C

Propofol	18,75 mg/ml
Dexmedetomidine	1,88 µg/ml

25°C

Propofol	10,34 mg/ml
Dexmedetomidine	14,48 µg/ml

25°C

Propofol	16,22 mg/ml
Dexmedetomidine	5,68 µg/ml

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