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References   References 4433  
Type : Journal
Web link : https://doi.org/10.1016/j.clinthera.2020.01.017
Research teams : Philadelphia - Philadelphia College of Pharmacy and Science
Authors : Ghazi I.M, El Nekidy W.S, Sood A, Dulku A, Patel R, Patel K.
Title : Y-site Administration of Imipenem/Cilastatin/ Relebactam With Common Intravenous Medications
Reference : Clin Ther ; 42, 3: 475-485. 2020
Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
List of drugs
injectionBumetanide Diuretic
Compatible 0,25 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionCalcium chloride Electrolyte
Compatible 40 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionCisatracurium besylate Curarimimetic
Compatible 0,4 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 1 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionDexmedetomidine Sympathomimetic
Compatible 4 µg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + Sodium chloride 0,9%
injectionDigoxin Cardiotonic
Compatible 0,25 µg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionDiltiazem hydrochloride Anti-arrhythmic
Compatible 5 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Compatible 4 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 3,2 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionEnalaprilate Antihypertensive
Compatible 1,25 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 50 µg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionEptifibatide Anticoagulant
Compatible 2 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionEsomeprazole sodium Proton pump inhibitor
Compatible 0,8 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionFamotidine Antihistamine (H2)
Compatible 4 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionFentanyl citrate Analgesic
Compatible 50 µg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionFosphenytoin sodium Antiepileptic
Compatible 37,5 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionFurosemide Diuretic
Incompatible 10 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionHaloperidol lactate Neuroleptic
Incompatible 5 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionHuman albumin Various
Compatible 50 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionHydrocortisone sodium succinate Anti-inflammatory
Incompatible 1 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionImipenem-Cilastatin / Relebactam Antibiotic
Compatible 5 mg/ml + injectionBumetanide 0,25 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionCalcium chloride 40 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionCalcium gluconate 40 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionCisatracurium besylate 0,4 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + injectionDexamethasone sodium phosphate 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionDexmedetomidine 4 µg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + injectionDigoxin 0,25 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionDiltiazem hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionDiphenhydramine hydrochloride 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionDobutamine hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionDopamine hydrochloride 3,2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionEnalaprilate 1,25 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionEpinephrine hydrochloride 50 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionEptifibatide 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionEsmolol hydrochloride 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionEsomeprazole sodium 0,8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionFamotidine 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionFentanyl citrate 50 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionFosphenytoin sodium 37,5 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + injectionFurosemide 10 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + injectionHaloperidol lactate 5 mg/ml + Glucose 5%
Compatible 5 mg/ml + injectionHeparin sodium 1000 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionHuman albumin 50 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + injectionHydrocortisone sodium succinate 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionInsulin 1 UI/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + injectionInsulin aspart 1 UI/ml + Sodium chloride 0,9%
Incompatible 5 mg/ml + injectionInsulin glulisine 1 U/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionInsulin lyspro 1 UI/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + injectionKetorolac tromethamine 30 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + injectionLabetalol hydrochloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionLidocaine hydrochloride 10 mg/ml + Glucose 5%
Compatible 5 mg/ml + injectionMagnesium sulfate 200 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionMesna 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionMethylprednisolone sodium succinate 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionMetoclopramide hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionMetoprolol tartrate 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionMilrinone lactate 0,2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionNaloxone hydrochloride 0,004 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionNitroglycerin 0,4 mg/ml + Glucose 5%
Compatible 5 mg/ml + injectionNorepinephrine bitartrate 0,032 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionOndansetron hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionPantoprazole sodium 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionPhenylephrine hydrochloride 0,2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + injectionPhenytoin sodium 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionPotassium phosphate 0,4 mmol/ml + NaCl 0,9% or Glucose 5%
Incompatible 5 mg/ml + injectionPropofol 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionRanitidine hydrochloride 2,5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionRocuronium bromide 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionVasopressin 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionInsulin Glucose-lowering
Compatible 1 UI/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + Sodium chloride 0,9%
injectionInsulin aspart Glucose-lowering
Compatible 1 UI/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + Sodium chloride 0,9%
injectionInsulin glulisine Glucose-lowering
Incompatible 1 U/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionInsulin lyspro Glucose-lowering
Compatible 1 UI/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + Sodium chloride 0,9%
injectionKetorolac tromethamine Anti-inflammatory
Compatible 30 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionLabetalol hydrochloride Beta-blocker
Incompatible 2 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionLidocaine hydrochloride Local anesthetic
Compatible 10 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + Glucose 5%
injectionMagnesium sulfate Electrolyte
Compatible 200 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionMesna Cytoprotective
Compatible 20 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionMetoclopramide hydrochloride Antiemetic
Compatible 1 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionMetoprolol tartrate Anti-arrhythmic
Compatible 1 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionMidazolam hydrochloride Anxiolytic
Compatible 1 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionMilrinone lactate Cardiotonic
Compatible 0,2 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionNaloxone hydrochloride Antidote
Compatible 0,004 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionNitroglycerin Vasodilator
Compatible 0,4 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + Glucose 5%
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0,032 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionOndansetron hydrochloride Antiemetic
Compatible 1 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionPantoprazole sodium Proton pump inhibitor
Compatible 4 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionPhenylephrine hydrochloride Sympathomimetic
Compatible 0,2 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionPhenytoin sodium Antiepileptic
Incompatible 5 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionPotassium phosphate Electrolyte
Compatible 0,4 mmol/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionPropofol General anesthetic
Incompatible 10 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2,5 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionRocuronium bromide Curarimimetic
Compatible 5 mg/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionVasopressin Hormone
Compatible 1 UI/ml + injectionImipenem-Cilastatin / Relebactam 5 mg/ml + NaCl 0,9% or Glucose 5%
  Mentions Légales