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References   References 44  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/53/14/1701
Research teams : Baltimore - Alpharma, Research and Development
Authors : Baaske DM, DeMay JF, Latona CA, Mirmira S, Sigvardson KW.
Title : Stability of nicardipine hydrochloride in intravenous solutions.
Reference : Am J Health-Syst Pharm ; 53: 1701-1705. 1996
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionNicardipine hydrochloride Vasodilator
Factors which affect stability Solvent NaHCO3 Induces Degradation
Factors which affect stability Container Polyvinyl chloride Induces Adsorption
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,05 & 0,5 mg/ml 18°C-28°C Light
7 Day
Stability in solutions Glass Ringer’s lactate solution 0,05 & 0,5 mg/ml 18°C-28°C Light
7 Day
Compatible 0.05 & 0.5 mg/ml + injectionPotassium chloride 40 mEq/l + Glucose 5%
Incompatible 0,05 & 0,5 mg/ml + injectionSodium bicarbonate 50 mg/ml + None
Incompatible 0.05 & 0.5 mg/ml + NaHCO3
injectionPotassium chloride Electrolyte
Compatible 40 mEq/l + injectionNicardipine hydrochloride 0.05 & 0.5 mg/ml + Glucose 5%
injectionSodium bicarbonate Electrolyte
Incompatible 50 mg/ml + injectionNicardipine hydrochloride 0,05 & 0,5 mg/ml + None
  Mentions Légales