Last update :
06/05/2024
InfoStab
Infostab
List of drugs
List of drugs
Summary lists
Summary lists
Search for compatibilities
Search for compatibilities
Y-site compatibility table
Y-site compatibility table
References
References
Research teams
Research teams
Valistab
Valistab
Poster
Poster
Links
Links
Sponsors
Sponsors
Authors
Authors
User’s guide
User’s guide
Newsletter
Newsletter
References   References 44  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/53/14/1701
Research teams : Baltimore - Alpharma, Research and Development
Authors : Baaske DM, DeMay JF, Latona CA, Mirmira S, Sigvardson KW.
Title : Stability of nicardipine hydrochloride in intravenous solutions.
Reference : Am J Health-Syst Pharm ; 53: 1701-1705. 1996
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionNicardipine hydrochloride Vasodilator
Factors which affect stability Solvent NaHCO3 Induces Degradation
Factors which affect stability Container Polyvinyl chloride Induces Adsorption
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,05 & 0,5 mg/ml 18°C-28°C Light
7 Day
Stability in solutions Glass Ringer’s lactate solution 0,05 & 0,5 mg/ml 18°C-28°C Light
7 Day
Compatible 0.05 & 0.5 mg/ml + InjectionPotassium chloride 40 mEq/l + Glucose 5%
Incompatible 0,05 & 0,5 mg/ml + InjectionSodium bicarbonate 50 mg/ml + None
Incompatible 0.05 & 0.5 mg/ml + NaHCO3
InjectionPotassium chloride Electrolyte
Compatible 40 mEq/l + InjectionNicardipine hydrochloride 0.05 & 0.5 mg/ml + Glucose 5%
InjectionSodium bicarbonate Electrolyte
Incompatible 50 mg/ml + InjectionNicardipine hydrochloride 0,05 & 0,5 mg/ml + None
  Mentions Légales