Last update :
03/05/2024
References   References 4200  
Type : Journal
Web link : https://ejhp.bmj.com/content/early/2018/10/15/ejhpharm-2018-001553

Research teams : Fribourg - University Hospital Freiburg, Department of Pharmacy
Authors : Macorigh C, Guibbert V, Casanova M, Haenni C.
Title : Stability study of hydromorphone and bupivacaine mixture by HPLC-UV.
Reference : EJHP 2018

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
InjectionBupivacaine hydrochloride Local anesthetic
Compatible 10 mg/ml + InjectionHydromorphone hydrochloride 15 mg/ml + None
InjectionHydromorphone hydrochloride Analgesic
Compatible 15 mg/ml + InjectionBupivacaine hydrochloride 10 mg/ml + None
Stability of mixtures
Not specified None 37°C Protect from light
Injection Hydromorphone hydrochloride 15 mg/ml
Injection Bupivacaine hydrochloride 10 mg/ml
90 Day

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