Last update :
03/05/2024
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References 4062
Type :
Journal
Web link :
https://ijpc.com/Abstracts/Abstract.cfm?ABS=4436
Research teams :
Waltham - TESARO Inc, Waltham
Authors :
Wu George, Powers Dan, Yeung S, Chen F, Neelon K.
Title :
Compatibility and stability of VARUBI (Rolapitant) injectable emulsion admixed with intravenous palonosetron hydrochloride injection and dexamethasone sodium phosphate injection.
Reference :
Int J Pharm Compound ;22,1:76-85 2018
Level of Evidence :
Physical stability :
Chemical stability :
Other methods :
Comments :
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products not observed in real conditions
List of drugs
Dexamethasone sodium phosphate
Palonosetron hydrochloride
Rolapitant
2-8°C
Rolapitant
1,6 mg/ml
Palonosetron hydrochloride
2,1 µg/ml
Dexamethasone sodium phosphate
0,178 mg/ml
48
2-8°C
Rolapitant
1,6 mg/ml
Palonosetron hydrochloride
2,1 µg/ml
Dexamethasone sodium phosphate
0,093 mg/ml
48
20-25°C
Rolapitant
1,6 mg/ml
Palonosetron hydrochloride
2,1 µg/ml
Dexamethasone sodium phosphate
0,093 mg/ml
24
20-25°C
Rolapitant
1,6 mg/ml
Palonosetron hydrochloride
2,1 µg/ml
Dexamethasone sodium phosphate
0,178 mg/ml
24
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