Last update :
28/04/2024
References   References 3821  
Type : Journal
Web link : http://www.ajhp.org/content/72/24/2182.abstract

Research teams : Philadelphia - Christopher’s Hospital for Children
Authors : Cies J.J, Moore W.S, Chopra A, Lu G, Mason R.W.
Title : Stability of furosemide and chlorothiazide stored in syringes.
Reference : Am J Health-Syst Pharm ; 72:2182-2188 2015

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Increased concentration unexplained
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products not observed in real conditions

List of drugs
InjectionChlorothiazide sodium Diuretic
Stability in solutions Polypropylen Syringe Glucose 5% 10 mg/ml 25°C Protect from light
96 Hour
Compatible 10 mg/ml + InjectionFurosemide 1 mg/ml + Glucose 5%
InjectionFurosemide Diuretic
Stability in solutions Polypropylen Syringe Glucose 5% 1 mg/ml 25°C Protect from light
96 Hour
Compatible 1 mg/ml + InjectionChlorothiazide sodium 10 mg/ml + Glucose 5%
Stability of mixtures
Polypropylen Syringe Glucose 5% 25°C Protect from light
Injection Chlorothiazide sodium 10 mg/ml
Injection Furosemide 1 mg/ml
96 Hour

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