Last update :
22/08/2024
References   References 3728  
Type : Journal
Web link : http://www.ajhp.org/content/71/15/1288.abstract

Research teams : Marseille - La Timone University Teaching Hospital, Pharmacy Department
Authors : Correard F, Savry A, Gauthier-Villano L, Pisano P, Pourroy B.
Title : Visual compatibility of defibrotide with selected drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 71: 1288-1291. 2014

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAciclovir sodium Antiviral
Compatible 10 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionAlizapride hydrochloride Antiemetic
Compatible 0.96 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionAmikacin sulfate Antibiotic
Incompatible 5 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionAmoxicillin sodium Antibiotic
Compatible 40 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionAmphotericin B liposomale Antifungal
Compatible 2 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionCaspofungin acetate Antifungal
Compatible 0.4 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionCeftazidime Antibiotic
Compatible 80 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionCeftriaxone disodium Antibiotic
Compatible 100 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionCiclosporin Immunosuppressant
Compatible 1.27 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionClonazepam Antiepileptic
Compatible 0.02 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionClonidine hydrochloride Antihypertensive
Compatible 0.0024 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionCo-trimoxazole Antibiotic
Compatible 0.64/3.2 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionDeferoxamine mesylate Chelator
Compatible 6.7 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionDefibrotide Anticoagulant
Compatible 8 mg/ml + injectionAciclovir sodium 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionAlizapride hydrochloride 0.96 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + injectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionAmoxicillin sodium 40 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionAmphotericin B liposomale 2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionCaspofungin acetate 0.4 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionCeftazidime 80 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionCeftriaxone disodium 100 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionCiclosporin 1.27 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionClonazepam 0.02 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionClonidine hydrochloride 0.0024 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionCo-trimoxazole 0.64/3.2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionDeferoxamine mesylate 6.7 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionFoscarnet sodium 24 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionFosfomycin 40 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + injectionFurosemide 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionGanciclovir sodium 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionHeparin sodium 373 UI/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionHuman albumin 200 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionHydrocortisone sodium succinate 1.9 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionHydroxyzine dihydrochloride 0.79 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionImipenem - cilastatin sodium 9.94/9.94 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + injectionImipenem - cilastatin sodium 9.94/9.94 mg/ml + Glucose 5%
Compatible 8 mg/ml + injectionMesna 4.76 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + injectionMethylprednisolone sodium succinate 10 mg/ml + Glucose 5%
Compatible 8 mg/ml + injectionMethylprednisolone sodium succinate 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + injectionMycophenolate mofetil 11.9 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionNalbuphine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionNefopam 5 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + injectionNicardipine hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionOndansetron hydrochloride 0.16 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionPantoprazole sodium 1.6 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionParacetamol 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionPhloroglucinol 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionTeicoplanine 125 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + injectionTobramycin sulfate 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionTranexamic acid 100 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + injectionVancomycin hydrochloride 10.4 mg/ml + Sodium chloride 0,9%
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionFoscarnet sodium Antiviral
Compatible 24 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionFosfomycin Antibiotic
Compatible 40 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionFurosemide Diuretic
Incompatible 10 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionGanciclovir sodium Antiviral
Compatible 10 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionHeparin sodium Anticoagulant
Compatible 373 UI/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionHuman albumin Various
Compatible 200 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1.9 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionHydroxyzine dihydrochloride Anxiolytic
Compatible 0.79 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionImipenem - cilastatin sodium Antibiotic
Compatible 9.94/9.94 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
Incompatible 9.94/9.94 mg/ml + injectionDefibrotide 8 mg/ml + Glucose 5%
injectionMesna Cytoprotective
Compatible 4.76 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 10 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
Incompatible 10 mg/ml + injectionDefibrotide 8 mg/ml + Glucose 5%
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionMidazolam hydrochloride Anxiolytic
Incompatible 5 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionMycophenolate mofetil Immunosuppressant
Incompatible 11.9 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionNalbuphine hydrochloride Antidote
Compatible 2 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionNaloxone hydrochloride Antidote
Compatible 0.4 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionNefopam Analgesic
Compatible 5 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionNicardipine hydrochloride Vasodilator
Incompatible 0.5 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionOndansetron hydrochloride Antiemetic
Compatible 0.16 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionPantoprazole sodium Proton pump inhibitor
Compatible 1.6 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionParacetamol Analgesic
Compatible 10 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionPhloroglucinol  Antispasmodic
Compatible 10 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionTeicoplanine Antibiotic
Compatible 125 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionTobramycin sulfate Antibiotic
Incompatible 10 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionTranexamic acid Anti-bleeding
Compatible 100 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
injectionVancomycin hydrochloride Antibiotic
Incompatible 10.4 mg/ml + injectionDefibrotide 8 mg/ml + Sodium chloride 0,9%

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