Last update :
19/11/2024
References   References 36  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/52/21/2423

Research teams : Bethesda - National Institutes of Health Clinical Center
Authors : Alex S, Gupta SL, Minor JR, Turcovski-Corrales S, Gallelli JF, Taub D, Piscitelli SC.
Title : Compatibility and activity of aldesleukin (recombinant interleukin-2) in presence of selected drugs during simulated Y-site administration: Evaluation of three methods.
Reference : Am J Health-Syst Pharm ; 52: 2423-2426. 1995

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAldesleukin Anticancer drug
Compatible 0.0338 MUI/ml + injectionAmphotericin B 1.6 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + injectionCalcium gluconate 100 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + injectionCo-trimoxazole + Glucose 5%
Compatible 0.0338 MUI/ml + injectionDiphenhydramine hydrochloride 50 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + injectionDopamine hydrochloride 1.6 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + injectionFluconazole 2 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + injectionFoscarnet sodium 24 mg/ml + Glucose 5%
Incompatible 0.0338 MUI/ml + injectionGanciclovir sodium 10 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + injectionHeparin sodium 100 UI/ml + Glucose 5%
Incompatible 0.0338 MUI/ml + injectionLorazepam 2 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + injectionMagnesium sulfate 20 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + injectionMetoclopramide hydrochloride 5 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + injectionOndansetron hydrochloride 0.7 mg/ml + Glucose 5%
Incompatible 0.0338 MUI/ml + injectionPentamidine isetionate 6 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + injectionPotassium chloride 200 mEq/l + Glucose 5%
Incompatible 0.0338 MUI/ml + injectionProchlorperazine edysilate 5 mg/ml + Glucose 5%
Incompatible 0.0338 MUI/ml + injectionPromethazine hydrochloride 25 mg/ml + Glucose 5%
Compatible 0.0338 MUI/ml + injectionRanitidine hydrochloride 1 mg/ml + Glucose 5%
injectionAmphotericin B Antifungal
Compatible 1.6 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionCalcium gluconate Electrolyte
Compatible 100 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionCo-trimoxazole Antibiotic
Compatible + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 1.6 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionFoscarnet sodium Antiviral
Compatible 24 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionGanciclovir sodium Antiviral
Incompatible 10 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionLorazepam Anxiolytic
Incompatible 2 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionMagnesium sulfate Electrolyte
Compatible 20 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionOndansetron hydrochloride Antiemetic
Compatible 0.7 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionPentamidine isetionate Antibiotic
Incompatible 6 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionPotassium chloride Electrolyte
Compatible 200 mEq/l + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionProchlorperazine edysilate Neuroleptic
Incompatible 5 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionPromethazine hydrochloride Antihistamine (H1)
Incompatible 25 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 1 mg/ml + injectionAldesleukin 0.0338 MUI/ml + Glucose 5%

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