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References   References 345  
Type : Journal
Web link : https://www.cjhp-online.ca/index.php/cjhp/article/view/2219
Research teams : Toronto - Sunnybrook Health Sciences Center
Authors : Walker SE, Meinders A, Tailor H.
Title : Stability and compatibility of reconstituted sterile hydromorphone with midazolam.
Reference : Can J Hosp Pharm ; 49: 290-298. 1996
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionHydromorphone hydrochloride Analgesic
Compatible 0.5 >> 45 mg/ml + injectionMidazolam hydrochloride 0.1 >> 4.5 mg/ml + NaCl 0,9% or Glucose 5%
injectionMidazolam hydrochloride Anxiolytic
Compatible 0.1 >> 4.5 mg/ml + injectionHydromorphone hydrochloride 0.5 >> 45 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Not specified NaCl 0,9% or Glucose 5% 23°C Protect from light
injection Midazolam hydrochloride 0.1 & 0.5 mg/ml
injection Hydromorphone hydrochloride 2 & 20 mg/ml
23 Day
Not specified NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Midazolam hydrochloride 0.1 & 0.5 mg/ml
injection Hydromorphone hydrochloride 2 & 20 mg/ml
23 Day
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