Last update :
19/11/2024
References   References 3115  
Type : Journal
Web link : http://www.em-consulte.com/article/253876

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Athanasopoulos A, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L.
Title : Long term stability of the hydrochloride of tramadol and alizapride in dextrose 5% polyolefin bags at 5 +/- 3°C.
Reference : Ann Pharm Fr ; 68: 157-162. 2010

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
injectionAlizapride hydrochloride Antiemetic
Compatible 0,5 mg/ml + injectionTramadol hydrochloride 1 mg/ml + Glucose 5%
injectionTramadol hydrochloride Analgesic
Compatible 1 mg/ml + injectionAlizapride hydrochloride 0,5 mg/ml + Glucose 5%
Stability of mixtures
Polyethylene Glucose 5% 2-8°C Not specified
injection Alizapride hydrochloride 0,41 mg/ml
injection Tramadol hydrochloride 0,82 mg/ml
32 Day

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