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References   References 2353  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=1193
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Xu Q.A, Trissel L.A, Zhang Y, Williams K.Y.
Title : Compatibility and stability of linezolid injection admixted with gentamicin sulfate and tobramycin sulfate.
Reference : Int J Pharm Compound ; 4, 6: 476-479. 2000
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
Comments : 
No comments for the degradation products
List of drugs
InjectionGentamicin sulfate Antibiotic
Compatible 0,75 mg/ml + InjectionLinezolid 1,80 mg/ml
InjectionLinezolid Antibiotic
Compatible 1,80 mg/ml + InjectionGentamicin sulfate 0,75 mg/ml
Compatible 1,80 mg/ml + InjectionTobramycin sulfate 0,80 mg/ml
InjectionTobramycin sulfate Antibiotic
Compatible 0,80 mg/ml + InjectionLinezolid 1,80 mg/ml
Stability of mixtures
Polyolefine None 23°C Protect from light
Injection Linezolid 1,80 mg/ml
Injection Tobramycin sulfate 0,80 mg/ml
1 Day
Polyolefine None 23°C Protect from light
Injection Linezolid 1,80 mg/ml
Injection Gentamicin sulfate 0,75 mg/ml
5 Day
Polyolefine None 4°C Protect from light
Injection Linezolid 1,80 mg/ml
Injection Gentamicin sulfate 0,75 mg/ml
7 Day
Polyolefine None 4°C Protect from light
Injection Linezolid 1,80 mg/ml
Injection Tobramycin sulfate 0,80 mg/ml
7 Day
  Mentions Légales