Last update :
19/11/2024
References   References 2184  
Type : Journal
Web link : https://www.sciencedirect.com/science/article/pii/S0885392406004714

Research teams : Amsterdam - Academic Medical center, Department of Pharmacy
Authors : Vranken JH, van Kan HJM, ven der Vegt MH.
Title : Stability and compatibility of a meperidine-clonidine mixture in portable pump reservoirs for the management of cancer pain syndromes.
Reference : J Pain Symptom Manage ; 32, 4: 297-299. 2006

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionClonidine hydrochloride Antihypertensive
Compatible 0.003 mg/ml + injectionPethidine hydrochloride 8 mg/ml + Sodium chloride 0,9%
injectionPethidine hydrochloride Analgesic
Compatible 8 mg/ml + injectionClonidine hydrochloride 0.003 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 25°C Light
injection Pethidine hydrochloride 8 mg/ml
injection Clonidine hydrochloride 0,003 mg/ml
21 Day

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