Last update :
27/11/2024
References   References 1708  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=349

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Xu QA, Trissel LA, Pham L.
Title : Physical and chemical stability of low and high concentrations of morphine sulfate with clonidine hydrochloride packaged in plastic syringes.
Reference : Int J Pharm Compound ; 6: 66-69. 2002

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 

List of drugs
injectionClonidine hydrochloride Antihypertensive
Compatible 4 mg/ml + injectionMorphine sulfate 50 mg/ml + Water for Injection
Compatible 0.25 mg/ml + injectionMorphine sulfate 5 mg/ml + Sodium chloride 0,9%
injectionMorphine sulfate Analgesic
Compatible 50 mg/ml + injectionClonidine hydrochloride 4 mg/ml + Water for Injection
Compatible 5 mg/ml + injectionClonidine hydrochloride 0.25 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylene Water for Injection 23°C Light
injection Morphine sulfate 50 mg/ml
injection Clonidine hydrochloride 4 mg/ml
60 Day
Polypropylene Water for Injection 37°C Protect from light
injection Morphine sulfate 50 mg/ml
injection Clonidine hydrochloride 4 mg/ml
48 Hour
Polypropylene Water for Injection 4°C Protect from light
injection Morphine sulfate 50 mg/ml
injection Clonidine hydrochloride 4 mg/ml
60 Day
Polypropylene Sodium chloride 0,9% 23°C Light
injection Morphine sulfate 5 mg/ml
injection Clonidine hydrochloride 0,25 mg/ml
60 Day
Polypropylene Sodium chloride 0,9% 37°C Protect from light
injection Morphine sulfate 5 mg/ml
injection Clonidine hydrochloride 0,25 mg/ml
48 Hour
Polypropylene Sodium chloride 0,9% 4°C Protect from light
injection Morphine sulfate 5 mg/ml
injection Clonidine hydrochloride 0,25 mg/ml
60 Day

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