Last update :
29/10/2024
References   References 1601  
Type : Journal
Web link : http://www.factsandcomparisons.com/HospitalPharm/?id=67

Research teams : Albuquerque - University of New Mexico Health Sciences Center, College of Pharmacy
Authors : Godwin DA, Kim NH, Zuniga R.
Title : Stability of a baclofen and clonidine hydrochloride admixture for intrathecal administration.
Reference : Hosp Pharm ; 36: 950-954. 2001

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
injectionBaclofen Various
Stability in solutions Glass Sodium chloride 0,9% 1 mg/ml 37°C Protect from light
70 Day
Compatible 1 mg/ml + injectionClonidine hydrochloride 0,2 mg/ml + Sodium chloride 0,9%
injectionClonidine hydrochloride Antihypertensive
Stability in solutions Glass Sodium chloride 0,9% 0,2 mg/ml 37°C Protect from light
70 Day
Compatible 0,2 mg/ml + injectionBaclofen 1 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Glass Sodium chloride 0,9% 37°C Protect from light
injection Baclofen 1 mg/ml
injection Clonidine hydrochloride 0,2 mg/ml
70 Day

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