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References   References 1508  
Type : Journal
Web link : http://dx.doi.org/10.1136/ejhpharm-2014-000478
Research teams : Lausanne - University Hospital, Department of Pharmacy
Authors : Voirol P, Berger-Gryllaki M, Pannatier A, Eggimann P, Sadeghipour F.
Title : Visual compatibility of insulin aspart with intravenous drugs frequently used in ICU.
Reference : EJHP ;22:123-124. 2015
Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
List of drugs
injectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 6 & 12 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionCeftazidime Antibiotic
Compatible 20 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionCeftriaxone disodium Antibiotic
Compatible 10 & 50 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionCiclosporin Immunosuppressant
Compatible 1 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionClonazepam Antiepileptic
Compatible 0,04 & 1 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionClonidine hydrochloride Antihypertensive
Compatible 0,0125 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionDihydralazine mesilate Vasodilator
Compatible 0,05 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionDiltiazem hydrochloride Anti-arrhythmic
Compatible 1 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Compatible 5 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 5 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 60 & 300 µg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionEsomeprazole sodium Proton pump inhibitor
Incompatible 1 mg/ml + injectionInsulin aspart 1 UI/ml + Glucose 5%
Compatible 1 mg/ml + injectionInsulin aspart 1 UI/ml + Sodium chloride 0,9%
injectionFentanyl citrate Analgesic
Compatible 5, 25 & 50 µg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionFurosemide Diuretic
Compatible 1 & 5 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 50 & 400 UI/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionImipenem - cilastatin sodium Antibiotic
Incompatible 5 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionInsulin aspart Glucose-lowering
Compatible 1 UI/ml + injectionAmiodarone hydrochloride 6 & 12 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionCeftazidime 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionCeftriaxone disodium 10 & 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionCiclosporin 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionClonazepam 0,04 & 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionClonidine hydrochloride 0,0125 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionDihydralazine mesilate 0,05 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionDiltiazem hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionDobutamine hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionDopamine hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionEpinephrine hydrochloride 60 & 300 µg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 UI/ml + injectionEsomeprazole sodium 1 mg/ml + Glucose 5%
Compatible 1 UI/ml + injectionEsomeprazole sodium 1 mg/ml + Sodium chloride 0,9%
Compatible 1 UI/ml + injectionFentanyl citrate 5, 25 & 50 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionFurosemide 1 & 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionHeparin sodium 50 & 400 UI/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 UI/ml + injectionImipenem - cilastatin sodium 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionIsoprenaline hydrochloride 0,05 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionLabetalol hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionLevetiracetam 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionMagnesium sulfate 20 & 100 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 UI/ml + injectionMeropenem 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionMidazolam hydrochloride 1 & 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionMilrinone lactate 0,25 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionNifedipine 0,1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionNimodipine 0,2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionNitroglycerin 0,5 & 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionNitroprusside sodium 1,25 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionNorepinephrine bitartrate 0,12 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionOctreotide acetate 0,01 & 0,02 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 UI/ml + injectionPantoprazole sodium 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionPiperacillin sodium / tazobactam 45 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionPotassium chloride 1 & 2 mEq/l + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionPropofol 10 & 20 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionRemifentanil hydrochloride 100 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionSalbutamol sulfate 0,1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionSodium thiosulfate 100 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionSufentanil citrate 0,005, 0,025 & 0,05 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionValproic acid 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionVancomycin hydrochloride 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionVasopressin 0,5 & 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionVerapamil hydrochloride 1,25 mg/ml + NaCl 0,9% or Glucose 5%
injectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0,05 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionLevetiracetam Antiepileptic
Compatible 5 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionMagnesium sulfate Electrolyte
Compatible 20 & 100 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionMeropenem Antibiotic
Incompatible 20 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionMidazolam hydrochloride Anxiolytic
Compatible 1 & 5 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionMilrinone lactate Cardiotonic
Compatible 0,25 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionMorphine hydrochloride Analgesic
Compatible 1 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionNifedipine Vasodilator
Compatible 0,1 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionNimodipine Antihypertensive
Compatible 0,2 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionNitroglycerin Vasodilator
Compatible 0,5 & 1 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionNitroprusside sodium Vasodilator
Compatible 1,25 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0,12 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionOctreotide acetate Various
Compatible 0,01 & 0,02 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionPantoprazole sodium Proton pump inhibitor
Incompatible 4 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionPiperacillin sodium / tazobactam Antibiotic
Compatible 45 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionPotassium chloride Electrolyte
Compatible 1 & 2 mEq/l + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionPropofol General anesthetic
Compatible 10 & 20 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionRemifentanil hydrochloride Analgesic
Compatible 100 µg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionSalbutamol sulfate Beta-stimulant
Compatible 0,1 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionSodium thiosulfate Antidote
Compatible 100 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionSufentanil citrate Analgesic
Compatible 0,005, 0,025 & 0,05 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionTirofiban Anticoagulant
Compatible 50 µg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionValproic acid Antiepileptic
Compatible 50 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionVasopressin Hormone
Compatible 0,5 & 1 UI/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
injectionVerapamil hydrochloride Anti-arrhythmic
Compatible 1,25 mg/ml + injectionInsulin aspart 1 UI/ml + NaCl 0,9% or Glucose 5%
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