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References   References 1058  
Type : Journal
Research teams : Brooklyn - Long Island University, Arnold and Marie Schwarz College of Pharmacy
Authors : Kirschenbaum HL, Aronoff W, Piltz GW, Perentesis GP, Cutie AJ.
Title : Compatibility and stability of dobutamine hydrochloride with large-volume parenterals and selected additives.
Reference : Am J Hosp Pharm ; 40: 1690-1691. 1983
Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
List of drugs
injectionAminophylline Various
Incompatible 1 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionBretylium tosilate Anti-arrhythmic
Incompatible 2 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionCalcium chloride Electrolyte
Incompatible 2 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionCalcium gluconate Electrolyte
Incompatible 2 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionDigoxin Cardiotonic
Incompatible 4 µg/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Factors which affect stability Solvent NaHCO3 Induces Degradation
Stability in solutions Glass NaCl 0,45% Glucose 5% 1 mg/ml 25°C Light
48 Hour
Stability in solutions Polyvinyl chloride NaCl 0,45% Glucose 5% 1 mg/ml 25°C Light
48 Hour
Incompatible 1 mg/ml + injectionAminophylline 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionBretylium tosilate 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionCalcium chloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionCalcium gluconate 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionDigoxin 4 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionDopamine hydrochloride 1.6 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionFurosemide 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionHeparin sodium 40 UI/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionLidocaine hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionMagnesium sulfate 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionPhenytoin sodium 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionPotassium chloride 160 mEq/l + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionProcainamide hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + injectionSodium bicarbonate 50 mg/ml
Incompatible 1 mg/ml + NaHCO3
injectionDopamine hydrochloride Cardiotonic
Compatible 1.6 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionFurosemide Diuretic
Incompatible 1 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 40 UI/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionInsulin Glucose-lowering
Incompatible 1 UI/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionLidocaine hydrochloride Local anesthetic
Compatible 4 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionMagnesium sulfate Electrolyte
Incompatible 2 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionPhenytoin sodium Antiepileptic
Incompatible 1 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionPotassium chloride Electrolyte
Incompatible 160 mEq/l + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionProcainamide hydrochloride Anti-arrhythmic
Compatible 1 mg/ml + injectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionSodium bicarbonate Electrolyte
Incompatible 50 mg/ml + injectionDobutamine hydrochloride 1 mg/ml
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