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References   References 1058  
Type : Journal
Research teams : Brooklyn - Long Island University, Arnold and Marie Schwarz College of Pharmacy
Authors : Kirschenbaum HL, Aronoff W, Piltz GW, Perentesis GP, Cutie AJ.
Title : Compatibility and stability of dobutamine hydrochloride with large-volume parenterals and selected additives.
Reference : Am J Hosp Pharm ; 40: 1690-1691. 1983
Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
List of drugs
InjectionAminophylline Various
Incompatible 1 mg/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionBretylium tosilate Anti-arrhythmic
Incompatible 2 mg/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCalcium chloride Electrolyte
Incompatible 2 mg/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCalcium gluconate Electrolyte
Incompatible 2 mg/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDigoxin Cardiotonic
Incompatible 4 µg/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionDobutamine hydrochloride Cardiotonic
Factors which affect stability Solvent NaHCO3 Induces Degradation
Stability in solutions Glass NaCl 0,45% Glucose 5% 1 mg/ml 25°C Light
48 Hour
Stability in solutions Polyvinyl chloride NaCl 0,45% Glucose 5% 1 mg/ml 25°C Light
48 Hour
Incompatible 1 mg/ml + InjectionAminophylline 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionBretylium tosilate 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionCalcium chloride 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionCalcium gluconate 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionDigoxin 4 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionDopamine hydrochloride 1.6 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionFurosemide 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionHeparin sodium 40 UI/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionLidocaine hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionMagnesium sulfate 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionPhenytoin sodium 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionPotassium chloride 160 mEq/l + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + InjectionProcainamide hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 1 mg/ml + InjectionSodium bicarbonate 50 mg/ml
Incompatible 1 mg/ml + NaHCO3
InjectionDopamine hydrochloride Cardiotonic
Compatible 1.6 mg/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionFurosemide Diuretic
Incompatible 1 mg/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionHeparin sodium Anticoagulant
Compatible 40 UI/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionInsulin Glucose-lowering
Incompatible 1 UI/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionLidocaine hydrochloride Local anesthetic
Compatible 4 mg/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionMagnesium sulfate Electrolyte
Incompatible 2 mg/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionPhenytoin sodium Antiepileptic
Incompatible 1 mg/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionPotassium chloride Electrolyte
Incompatible 160 mEq/l + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionProcainamide hydrochloride Anti-arrhythmic
Compatible 1 mg/ml + InjectionDobutamine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
InjectionSodium bicarbonate Electrolyte
Incompatible 50 mg/ml + InjectionDobutamine hydrochloride 1 mg/ml
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