Last update :
27/11/2024
References   References 865  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=213

Research teams : Ann Arbor - University of Michigan, College of Pharmacy
Authors : Bhatt-Mehta V, Hirata S.
Title : Physical compatibility and chemical stability of atracurium besylate and midazolam hydrochloride during intravenous coinfusion.
Reference : Int J Pharm Compound ; 2: 79-81. 1998

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
High Performance Liquid Chromatography - fluorescence detector
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Increased concentration unexplained

List of drugs
injectionAtracurium besylate Curarimimetic
Compatible 1 & 5 mg/ml + injectionMidazolam hydrochloride 0.1 & 0.5 mg/ml + Glucose 5%
injectionMidazolam hydrochloride Anxiolytic
Compatible 0.1 & 0.5 mg/ml + injectionAtracurium besylate 1 & 5 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 25°C Light
injection Midazolam hydrochloride 0,1 & 0,5 mg/ml
injection Atracurium besylate 1 & 5 mg/ml
3 Hour

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