Last update :
08/11/2024
References   References 3379  
Type : Journal
Web link : http://www.ajhp.org/content/70/6/520.abstract

Research teams : Clinton - Presbyterian College, School of Pharmacy
Authors : Fox L.M, Wilder A.G, Foushee J.A.
Title : Physical compatibility of various drugs with neonatal total parenteral nutrient solution during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ;70:520-524. 2013

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAmiodarone hydrochloride Anti-arrhythmic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 16 mg/ml + Parenteral nutrition (binary mixture)
injectionCaffeine citrate Respiratory stimulant
Compatible 20 mg/ml + injectionSodium bicarbonate + Parenteral nutrition (binary mixture)
injectionClindamycin phosphate Antibiotic
Compatible 24 mg/ml + Parenteral nutrition (binary mixture)
injectionEnalaprilate Antihypertensive
Compatible 0.08 mg/ml + Parenteral nutrition (binary mixture)
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 9.6 µg/ml + Parenteral nutrition (binary mixture)
injectionFluconazole Antifungal
Compatible 2 mg/ml + Parenteral nutrition (binary mixture)
injectionFosphenytoin sodium Antiepileptic
Compatible 50 mg/ml + Parenteral nutrition (binary mixture)
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 25.6 mg/ml + Parenteral nutrition (binary mixture)
injectionMetoclopramide hydrochloride Antiemetic
Compatible 0.58 mg/ml + Parenteral nutrition (binary mixture)
injectionMidazolam hydrochloride Anxiolytic
Compatible 0.48 mg/ml + Parenteral nutrition (binary mixture)
injectionPentobarbital sodium General anesthetic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 48 mg/ml + Parenteral nutrition (binary mixture)
injectionPhenobarbital sodium Antiepileptic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 64 mg/ml + Parenteral nutrition (binary mixture)
injectionRifampicin Antibiotic
Factors which affect stability Solvent Parenteral nutrition (binary mixture) Induces Degradation
Incompatible 0.3 >> 30 mg/ml + Parenteral nutrition (binary mixture)
injectionSodium bicarbonate Electrolyte
Compatible + injectionCaffeine citrate 20 mg/ml + Parenteral nutrition (binary mixture)

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