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References   References 280  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/52/21/2427
Research teams : Oklahoma City - University of Oklahoma Health Sciences Center, College of Pharmacy
Authors : Allen LV, Stiles ML, Prince SJ, Sylvestri MF.
Title : Stability of cefpirome sulfate in the presence of commonly used intensive care drugs during simulated Y-site injection.
Reference : Am J Health-Syst Pharm ; 52: 2427-2433. 1995
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions
List of drugs
injectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + injectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 5 mg/ml + injectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Compatible 5 mg/ml + injectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
injectionAmphotericin B Antifungal
Incompatible 0.1 mg/ml + injectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Incompatible 0.1 mg/ml + injectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Incompatible 0.1 mg/ml + injectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
injectionCefazolin sodium Antibiotic
Compatible 10 mg/ml + injectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Compatible 10 mg/ml + injectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 10 mg/ml + injectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
injectionCefpirome sulfate Antibiotic
Compatible 50 mg/ml + injectionAmikacin sulfate 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + injectionAmikacin sulfate 5 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + injectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,45%
Incompatible 50 mg/ml + injectionAmphotericin B 0.1 mg/ml + Ringer’s lactate solution
Incompatible 50 mg/ml + injectionAmphotericin B 0.1 mg/ml + Sodium chloride 0,45%
Incompatible 50 mg/ml + injectionAmphotericin B 0.1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + injectionCefazolin sodium 10 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + injectionCefazolin sodium 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + injectionCefazolin sodium 10 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + injectionClindamycin phosphate 12 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + injectionClindamycin phosphate 12 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + injectionClindamycin phosphate 12 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + injectionEpinephrine hydrochloride 100 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + injectionEpinephrine hydrochloride 100 µg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + injectionEpinephrine hydrochloride 100 µg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + injectionFluconazole 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + injectionFluconazole 2 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + injectionFluconazole 2 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + injectionGentamicin sulfate 1 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + injectionGentamicin sulfate 1 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + injectionGentamicin sulfate 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 mg/ml + injectionVancomycin hydrochloride 5 mg/ml + Sodium chloride 0,45%
Compatible 50 mg/ml + injectionVancomycin hydrochloride 5 mg/ml + Ringer’s lactate solution
Compatible 50 mg/ml + injectionVancomycin hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
injectionClindamycin phosphate Antibiotic
Compatible 12 mg/ml + injectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Compatible 12 mg/ml + injectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 12 mg/ml + injectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + injectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 4 mg/ml + injectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 4 mg/ml + injectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
injectionDopamine hydrochloride Cardiotonic
Compatible 0.8 mg/ml + injectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 0.8 mg/ml + injectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.8 mg/ml + injectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 100 µg/ml + injectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 100 µg/ml + injectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 100 µg/ml + injectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 2 mg/ml + injectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
injectionGentamicin sulfate Antibiotic
Compatible 1 mg/ml + injectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 1 mg/ml + injectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Compatible 1 mg/ml + injectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
injectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + injectionCefpirome sulfate 50 mg/ml + Sodium chloride 0,45%
Compatible 5 mg/ml + injectionCefpirome sulfate 50 mg/ml + Ringer’s lactate solution
Compatible 5 mg/ml + injectionCefpirome sulfate 50 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Cefazolin sodium 10 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Dexamethasone sodium phosphate 4 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Dopamine hydrochloride 0,8 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Epinephrine hydrochloride 0,1 µg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Amikacin sulfate 5 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Clindamycin phosphate 12 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Fluconazole 2 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Gentamicin sulfate 1 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Vancomycin hydrochloride 5 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Cefazolin sodium 10 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Dexamethasone sodium phosphate 4 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Dopamine hydrochloride 0,8 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Epinephrine hydrochloride 0,1 µg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Amikacin sulfate 5 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Clindamycin phosphate 12 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Fluconazole 2 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Gentamicin sulfate 1 mg/ml
8 Hour
Glass Ringer’s lactate solution 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Vancomycin hydrochloride 5 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Cefazolin sodium 10 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Dexamethasone sodium phosphate 4 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Dopamine hydrochloride 0,8 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Protect from light
injection Cefpirome sulfate 50 mg/ml
injection Epinephrine hydrochloride 0,1 µg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Amikacin sulfate 5 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Clindamycin phosphate 12 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Fluconazole 2 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Gentamicin sulfate 1 mg/ml
8 Hour
Glass Sodium chloride 0,45% 23°C Light
injection Cefpirome sulfate 50 mg/ml
injection Vancomycin hydrochloride 5 mg/ml
8 Hour
  Mentions Légales