Last update :
19/11/2024
References   References 1937  
Type : Journal
Web link : https://doi.org/10.1345/aph.1E124

Research teams : Lexington - Cubist Pharmaceuticals
Authors : Lai JJ, Brodeur SK.
Title : Physical and chemical stability of daptomycin with nine medications.
Reference : Ann Pharmacotherapy ; 38: 1612-1616. 2004

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
Changes in pH not commented or difficult to interpret
Degradation products not observed in real conditions
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Method not shown but the article refers to a validated method

List of drugs
injectionAztreonam Antibiotic
Compatible 16,7 mg/ml + injectionDaptomycin 16,7 mg/ml + Sodium chloride 0,9%
injectionCeftazidime Antibiotic
Compatible 16,7 mg/ml + injectionDaptomycin 16,7 mg/ml + Sodium chloride 0,9%
injectionCeftriaxone disodium Antibiotic
Compatible 16,7 mg/ml + injectionDaptomycin 16,7 mg/ml + Sodium chloride 0,9%
injectionDaptomycin Antibiotic
Compatible 16,7 mg/ml + injectionAztreonam 16,7 mg/ml + Sodium chloride 0,9%
Compatible 16,7 mg/ml + injectionCeftazidime 16,7 mg/ml + Sodium chloride 0,9%
Compatible 16,7 mg/ml + injectionCeftriaxone disodium 16,7 mg/ml + Sodium chloride 0,9%
Compatible 18,2 mg/ml + injectionDopamine hydrochloride 3,6 mg/ml + Sodium chloride 0,9%
Compatible 6,3 mg/ml + injectionFluconazole 1,3 mg/ml + Sodium chloride 0,9%
Compatible 19,2 mg/ml + injectionGentamicin sulfate 1,5 mg/ml + Sodium chloride 0,9%
Compatible 19,6 mg/ml + injectionHeparin sodium 98 UI/ml + Sodium chloride 0,9%
Compatible 14,3 mg/ml + injectionLevofloxacine 7,1 mg/ml + Sodium chloride 0,9%
Compatible 16,7 mg/ml + injectionLidocaine hydrochloride 3,3 mg/ml + Sodium chloride 0,9%
injectionDopamine hydrochloride Cardiotonic
Compatible 3,6 mg/ml + injectionDaptomycin 18,2 mg/ml + Sodium chloride 0,9%
injectionFluconazole Antifungal
Compatible 1,3 mg/ml + injectionDaptomycin 6,3 mg/ml + Sodium chloride 0,9%
injectionGentamicin sulfate Antibiotic
Compatible 1,5 mg/ml + injectionDaptomycin 19,2 mg/ml + Sodium chloride 0,9%
injectionHeparin sodium Anticoagulant
Compatible 98 UI/ml + injectionDaptomycin 19,6 mg/ml + Sodium chloride 0,9%
injectionLevofloxacine Antibiotic
Compatible 7,1 mg/ml + injectionDaptomycin 14,3 mg/ml + Sodium chloride 0,9%
injectionLidocaine hydrochloride Local anesthetic
Compatible 3,3 mg/ml + injectionDaptomycin 16,7 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Not specified Sodium chloride 0,9% 22°C-28°C Not specified
injection Daptomycin 16,7 mg/ml
injection Aztreonam 16,7 mg/ml
2 Hour
Not specified Sodium chloride 0,9% 22°C-28°C Not specified
injection Daptomycin 16,7 mg/ml
injection Ceftazidime 16,7 mg/ml
2 Hour
Not specified Sodium chloride 0,9% 22°C-28°C Not specified
injection Daptomycin 16,7 mg/ml
injection Ceftriaxone disodium 16,7 mg/ml
2 Hour
Not specified Sodium chloride 0,9% 22°C-28°C Not specified
injection Daptomycin 16,7 mg/ml
injection Lidocaine hydrochloride 3,3 mg/ml
2 Hour
Not specified Sodium chloride 0,9% 22°C-28°C Not specified
injection Daptomycin 18,2 mg/ml
injection Dopamine hydrochloride 3,6 mg/ml
2 Hour
Not specified Sodium chloride 0,9% 22°C-28°C Not specified
injection Daptomycin 19,2 mg/ml
injection Gentamicin sulfate 1,5 mg/ml
2 Hour
Not specified Sodium chloride 0,9% 22°C-28°C Not specified
injection Daptomycin 6,3 mg/ml
injection Fluconazole 1,3 mg/ml
2 Hour
Not specified Sodium chloride 0,9% 22°C-28°C Not specified
injection Daptomycin 19,6 mg/ml
injection Heparin sodium 5000 UI/ml
2 Hour
Not specified Sodium chloride 0,9% 22°C-28°C Not specified
injection Daptomycin 14,3 mg/ml
injection Levofloxacine 7,1 mg/ml
2 Hour

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