Last update :
08/11/2024
References   References 1902  
Type : Journal
Web link : http://www.cjhp-online.ca/index.php/cjhp/article/view/358

Research teams : Toronto - Sunnybrook Health Sciences Center
Authors : Walker SE, Wyllie A, Law S.
Title : Physical compatibility of pantoprazole with selected medications during simulated Y-site administration.
Reference : Can J Hosp Pharm ; 57, 2: 90-96. 2004

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAmpicillin sodium Antibiotic
Compatible 10 >> 40 mg/ml + injectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
injectionCefazolin sodium Antibiotic
Compatible 20 >> 40 mg/ml + injectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
injectionCeftriaxone disodium Antibiotic
Compatible 20 >> 40 mg/ml + injectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
injectionDimenhydrinate Antihistamine (H1)
Compatible 0.5 >> 1 mg/ml + injectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
injectionDobutamine hydrochloride Cardiotonic
Incompatible 1 >> 4 mg/ml + injectionPantoprazole sodium 0,16 >> 0,8 mg/ml + Sodium chloride 0,9%
Compatible < 4 mg/ml + injectionPantoprazole sodium < 0.05 mg/ml + Sodium chloride 0,9%
injectionDopamine hydrochloride Cardiotonic
Compatible 0.8 >> 3.2 mg/ml + injectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 16 >> 32 µg/ml + injectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
injectionEsmolol hydrochloride Beta-blocker
Incompatible > 2 mg/ml + injectionPantoprazole sodium > 0.12 mg/ml + Sodium chloride 0,9%
Incompatible < 2 mg/ml + injectionPantoprazole sodium < 0.12 mg/ml + Sodium chloride 0,9%
injectionFurosemide Diuretic
Compatible 1 >> 2 mg/ml + injectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
injectionInsulin Glucose-lowering
Compatible 5 >> 50 UI/ml + injectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
injectionMidazolam hydrochloride Anxiolytic
Incompatible > 0.1 mg/ml + injectionPantoprazole sodium > 0.01 mg/ml + Sodium chloride 0,9%
Compatible < 0.1 mg/ml + injectionPantoprazole sodium < 0.01 mg/ml + Sodium chloride 0,9%
injectionNitroglycerin Vasodilator
Compatible 0.1 >> 0.4 mg/ml + injectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
injectionNorepinephrine bitartrate Sympathomimetic
Incompatible > 0.064 mg/ml + injectionPantoprazole sodium > 0.8 mg/ml + Sodium chloride 0,9%
Compatible < 0.013 mg/ml + injectionPantoprazole sodium < 0.8 mg/ml + Sodium chloride 0,9%
Compatible < 0.064 mg/ml + injectionPantoprazole sodium < 0.1 mg/ml + Sodium chloride 0,9%
injectionOctreotide acetate Various
Compatible < 0.0015 mg/ml + injectionPantoprazole sodium < 0.8 mg/ml + Sodium chloride 0,9%
Incompatible > 0.004 mg/ml + injectionPantoprazole sodium > 0.5 mg/ml + Sodium chloride 0,9%
Compatible < 0.004 mg/ml + injectionPantoprazole sodium > 0.5 mg/ml + Sodium chloride 0,9%
injectionPantoprazole sodium Proton pump inhibitor
Compatible 0.16 >> 0.8 mg/ml + injectionAmpicillin sodium 10 >> 40 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + injectionCefazolin sodium 20 >> 40 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + injectionCeftriaxone disodium 20 >> 40 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + injectionDimenhydrinate 0.5 >> 1 mg/ml + Sodium chloride 0,9%
Incompatible 0,16 >> 0,8 mg/ml + injectionDobutamine hydrochloride 1 >> 4 mg/ml + Sodium chloride 0,9%
Compatible < 0.05 mg/ml + injectionDobutamine hydrochloride < 4 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + injectionDopamine hydrochloride 0.8 >> 3.2 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + injectionEpinephrine hydrochloride 16 >> 32 µg/ml + Sodium chloride 0,9%
Incompatible > 0.12 mg/ml + injectionEsmolol hydrochloride > 2 mg/ml + Sodium chloride 0,9%
Incompatible < 0.12 mg/ml + injectionEsmolol hydrochloride < 2 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + injectionFurosemide 1 >> 2 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + injectionInsulin 5 >> 50 UI/ml + Sodium chloride 0,9%
Incompatible > 0.01 mg/ml + injectionMidazolam hydrochloride > 0.1 mg/ml + Sodium chloride 0,9%
Compatible < 0.01 mg/ml + injectionMidazolam hydrochloride < 0.1 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + injectionNitroglycerin 0.1 >> 0.4 mg/ml + Sodium chloride 0,9%
Incompatible > 0.8 mg/ml + injectionNorepinephrine bitartrate > 0.064 mg/ml + Sodium chloride 0,9%
Compatible < 0.8 mg/ml + injectionNorepinephrine bitartrate < 0.013 mg/ml + Sodium chloride 0,9%
Compatible < 0.1 mg/ml + injectionNorepinephrine bitartrate < 0.064 mg/ml + Sodium chloride 0,9%
Compatible < 0.8 mg/ml + injectionOctreotide acetate < 0.0015 mg/ml + Sodium chloride 0,9%
Incompatible > 0.5 mg/ml + injectionOctreotide acetate > 0.004 mg/ml + Sodium chloride 0,9%
Compatible > 0.5 mg/ml + injectionOctreotide acetate < 0.004 mg/ml + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + injectionPotassium chloride 20 >> 4000 mEq/l + Sodium chloride 0,9%
Compatible 0.16 >> 0.8 mg/ml + injectionVasopressin 0.4 >> 1 UI/ml + Sodium chloride 0,9%
injectionPotassium chloride Electrolyte
Compatible 20 >> 4000 mEq/l + injectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%
injectionVasopressin Hormone
Compatible 0.4 >> 1 UI/ml + injectionPantoprazole sodium 0.16 >> 0.8 mg/ml + Sodium chloride 0,9%

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