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References   References 1045  
Type : Journal
Research teams : Houston - University of Houston, College of Pharmacy
Authors : Das Gupta V, Stewart KR.
Title : Stability of dobutamine hydrochloride and verapamil hydrochloride in 0.9% sodium chloride and 5 % dextrose injections.
Reference : Am J Hosp Pharm ; 41: 686-689. 1984
Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
List of drugs
injectionDobutamine hydrochloride Cardiotonic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,25 mg/ml 5°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,25 mg/ml 5°C Protect from light
7 Day
Compatible 0.25 mg/ml + injectionVerapamil hydrochloride 0.16 mg/ml + NaCl 0,9% or Glucose 5%
injectionVerapamil hydrochloride Anti-arrhythmic
Stability in solutions Glass NaCl 0,9% or Glucose 5% 0,16 mg/ml 5°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,16 mg/ml 5°C Protect from light
7 Day
Compatible 0.16 mg/ml + injectionDobutamine hydrochloride 0.25 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 5°C Protect from light
injection Dobutamine hydrochloride 0,25 mg/ml
injection Verapamil hydrochloride 0,16 mg/ml
7 Day
Polyvinyl chloride NaCl 0,9% or Glucose 5% 5°C Protect from light
injection Dobutamine hydrochloride 0,25 mg/ml
injection Verapamil hydrochloride 0,16 mg/ml
7 Day
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