Monographie - Thiotepa - Stabilis 4.0

Last update :
03/05/2024

Anticancer drug

Thiotepa

Injection

Stability in solutions

Stability of mixtures

Factors which affect stability

Compatibility

Route of administration

References

Pdf

Chemical structure

Tradename

Tradename

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Bedford	New Zealand
Ledertepa	Netherlands
Oncotiotepa	Spain
Thioplex	Italy
Thiotepa	Australia, Austria, Germany, Great Britain, Ireland, Sweden, United States of America

References

Injection

References : Thiotepa

	Type	Publication
3	Journal	Trissel LA, Martinez JF. Compatibility of amifostine with selected drugs during simulated Y-site administration. Am J Health-Syst Pharm 1995 ; 52: 2208-2212.
81	Journal	Trissel LA, Martinez JF. Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection. Am J Hosp Pharm 1994 ; 51: 672-678.
84	Journal	Trissel LA, Martinez JF. Visual, turbidimetric, and particle-content assessment of compatibility of vinorelbine tartrate with selected drugs during simulated Y-site injection. Am J Hosp Pharm 1994 ; 51: 495-499.
99	Journal	Trissel LA, Martinez JF. Compatibility of aztreonam with selected drugs during simulated Y-site administration. Am J Health-Syst Pharm 1995 ; 52: 1086-1090.
169	Journal	Trissel LA, Martinez JF. Physical compatibility of melphalan with selected drugs during simulated Y-site administration. Am J Hosp Pharm 1993 ; 50: 2359-2363.
182	Journal	Trissel LA, Gilbert DL, Martinez JF. Compatibility of granisetron hydrochloride with selected drugs during simulated Y-site administration. Am J Health-Syst Pharm 1997 ; 54: 56-60.
244	Journal	Trissel LA, Martinez JF. Compatibility of filgrastim with selected drugs during simulated Y-site administration. Am J Hosp Pharm 1994 ; 51: 1907-1913.
249	Journal	Trissel LA, Martinez JF. Compatibility of thiotepa (lyophilized) with selected drugs during simulated Y-site administration. Am J Health-Syst Pharm 1996 ; 53: 1041-1045.
302	Journal	Murray KM, Erkkila D, Gombotz WR, Pankey S. Stability of thiotepa (lyophilized) in 0.9% sodium chloride injection. Am J Health-Syst Pharm 1997 ; 54: 2588-2591.
307	Journal	Trissel LA, Martinez JF. Compatibility of allopurinol sodium with selected drugs during simulated Y-site administration. Am J Hosp Pharm 1994 ; 51: 1792-1799.
905	Journal	Trissel LA, Martinez JF. Screening teniposide for Y-site physical incompatibilities. Hosp Pharm 1994 ; 29: 1010-1017.
1410	Journal	Trissel LA, Martinez JF, Simmons M. Compatibility of etoposide phosphate with selected drugs during simulated Y-site injection. J Am Pharm Assoc 1999 ; 39: 141-145.
1423	Journal	Trissel LA, Martinez JF, Gilbert DL. Compatibility of gemcitabine hyrochloride with 107 selected drugs during simulated Y-site injection. J Am Pharm Assoc 1999 ; 39: 514-518.
3603	Manufacturer	Thiotepa (Tepadina®) - Summary of Product Characteristics Adienne Pharma Biotech 2011
4677	Poster	Linxweiler H, Thiesen J, Krämer I. Physicochemical stability of diluted "Thiotepa Riemser" infusion solutions in prefilled 5% glucose infusion bags. EAHP Congress Vienna 2022
4748	Journal	Linxweiler H, Thiesen J, Krämer I. Physicochemical Stability of Generic Thiotepa Concentrate and Ready-to-Administer Infusion Solutions for Conditioning Treatment. Pharmaceutics 2023 ,15, 309.

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