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Anticancer drug   Mitoxantrone dihydrochloride  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Bluxantron Ecuador
Bresnix Mexico
Ebexantron Austria
Elsep France
Formyxan Colombia, Ecuador, Mexico
Genefadrone Greece
Mitoxgen Argentina
Neotalem Mexico
Novantron Austria, Germany, Switzerland
Novantrone Belgium, Chile, Denmark, France, Greece, Hungary, Ireland, Italy, Luxembourg, Malaysia, Morocco, New Zealand, Norway, Republic of South Africa, Romania, Slovenia, Spain, Sweden, Thailand, Turkey, United Arab Emirates, United States of America
Onkotrone Australia, Germany, Great Britain, Italy, Luxembourg, Romania
Ralenova Germany
Refador Hungary
Santrone Egypt, Malaysia
Strimax Spain
Xantrosin Belgium
Stability in solutions   injection   Stability in solutions : Mitoxantrone dihydrochloride     
Container Solvent Concentration Temperature Storage Duration of stability References
Glass Sodium chloride 0,9% 0,04 >> 0,12 mg/ml 2-8°C Protect from light
28 Day
2344
Manufacturer's stability data
Glass Sodium chloride 0,9% 0,04 >> 0,12 mg/ml 20-25°C
7 Day
2344
Manufacturer's stability data
Glass Sodium chloride 0,9% 0,3 >> 0,5 mg/ml 2-8°C Protect from light
28 Day
2344
Manufacturer's stability data
Glass Sodium chloride 0,9% 0,3 >> 0,5 mg/ml 20-25°C Light
28 Day
2344
Manufacturer's stability data
Glass Glucose 5% 0,04 >> 0,5 mg/ml 2-8°C Protect from light
7 Day
2344
Manufacturer's stability data
Glass Glucose 5% 0,04 >> 0,5 mg/ml 20-25°C Light
7 Day
2344
Manufacturer's stability data
Polyvinyl chloride Water for Injection 0,2 mg/ml 37°C Protect from light
14 Day
484
Level of evidence A
Polyvinyl chloride Water for Injection 0,2 mg/ml 4°C Protect from light
14 Day
484
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,04 & 0,4 mg/ml 23°C Not specified
7 Day
828
Level of evidence B
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,04 & 0,4 mg/ml 4°C Protect from light
7 Day
828
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 0,3 >> 0,5 mg/ml 2-8°C Protect from light
28 Day
2344
Manufacturer's stability data
Polyvinyl chloride Sodium chloride 0,9% 0,3 >> 0,5 mg/ml 20-25°C Light
28 Day
2344
Manufacturer's stability data
Polyvinyl chloride Glucose 5% 0,04 >> 0,5 mg/ml 2-8°C Protect from light
7 Day
2344
Manufacturer's stability data
Polyvinyl chloride Glucose 5% 0,04 >> 0,5 mg/ml 20-25°C Light
7 Day
2344
Manufacturer's stability data
Polyethylene Sodium chloride 0,9% 0,04 >> 0,12 mg/ml 2-8°C Protect from light
28 Day
2344
Manufacturer's stability data
Polyethylene Sodium chloride 0,9% 0,04 >> 0,12 mg/ml 20-25°C
7 Day
2344
Manufacturer's stability data
Polyethylene Sodium chloride 0,9% 0,3 >> 0,5 mg/ml 2-8°C Protect from light
28 Day
2344
Manufacturer's stability data
Polyethylene Sodium chloride 0,9% 0,3 >> 0,5 mg/ml 20-25°C Light
28 Day
2344
Manufacturer's stability data
Polyethylene Glucose 5% 0,04 >> 0,5 mg/ml 2-8°C Protect from light
7 Day
2344
Manufacturer's stability data
Polyethylene Glucose 5% 0,04 >> 0,5 mg/ml 20-25°C
7 Day
2344
Manufacturer's stability data
Polypropylen Syringe Sodium chloride 0,9% 0,2 mg/ml 20°C Not specified
28 Day
1317
Level of evidence D
Polypropylen Syringe Sodium chloride 0,9% 0,2 mg/ml 4°C Protect from light
28 Day
1317
Level of evidence D
  Mentions Légales