Last update :
19/11/2024
Antimuscarinic   Scopolamine N-butyl bromide  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Buscapina Spain
Buscolysin Poland
Buscopan Australia, Austria, Belgium, Brazil, Canada, Egypt, Finland, Germany, Iceland, Luxembourg, Netherlands, New Zealand, Norway, Portugal, Sweden, Switzerland, Tunisia, Turkey, United Arab Emirates
Butilbromuro de hioscina Argentina, Colombia
Cifespasmo Argentina
Colobolina Argentina
Dolopina Ecuador
Escopolamina N butyl bromuro Chile
Hiocin Venezuela
Hioscina Argentina, Colombia, Peru
Hioscina butil bromuro Colombia, Peru
Hyocidic Iran
Hyoscine Australia
Hyoscine hydrobromide Canada
Hyotex Iran
Pasmodina Drawer Argentina
Rupe N Argentina
Scoburen France
Selpirans Venezuela
Spasmopan Tunisia
Xemol Turkey
References   injection   References : Scopolamine N-butyl bromide  
Type Publication
1230 Journal Regnard C, Pashley S, Westrope F.
Anti-emetic / diamorphine mixture compatibility in infusion pumps.
Br J Pharm Pract 1986 ; 8: 218-220.
1232 Journal Beatson C, Taylor A.
A physical compatibility study of furosemide & flucloxacillin injections.
Br J Pharm Pract 1987 ; 9: 223-226, 236.
1405 Journal Peterson GM, Miller KA, Galloway JG, Dunne PF.
Compatibility and stability of fentanyl admixtures in polypropylene syringes.
J Clin Pharm Ther 1998 ; 23: 67-72.
1757 Journal Schrijvers D, Tai-Apin C, De Smet MC, Cornil P, Vermorken JB, Bruyneel P.
Determination of compatibility and stability of drugs used in palliative care.
J Clin Pharm Ther 1998 ; 23: 311-314.
1847 Journal Anacardo R, Perilli O, Bartolini S, Gentile MM, Mazzeo P, Carlucci G.
Physicochemical compatibility between ketoprofen kysine salt injections (Artrosilene®) and pharmaceutical products frequently used for combined therapy by intravenous administration.
J Pharm Biomed Anal 2003 ; 32, 6: 1235-1241.
1966 Journal Barcia E, Reyes R, Azuara L, Sànchez Y, Negro S.
Stability and compatibility of binary mixtures of morphine hydrochloride with hyoscine-n-butyl bromide.
Support Care Cancer 2005 ; 13, 4: 239-245.
1970 Journal Barcia E, Reyes R, Azuara M.L, S?nchez Y, Negro S.
Compatibility of haloperidol and hyoscine-N-butyl bromide in mixtures for subcutaneous infusion to cancer patients in palliative care.
Support Care Cancer 2003 ; 11, 2: 107-113.
1971 Journal Azuara ML, Sanchez Y, Reyes R, Barcia E.
Physical compatibility and in vivo evaluation of drug mixtures forsubcutaneous infusion to cancer patients in palliative care.
Support Care Cancer 2001
2055 Journal Negro S, Reyes R, Azuara ML, Sanchez Y, Barcia E.
Morphine, haloperidol and hyoscine N-butyl bromide combined in sc infusion solutions : compatibility and stability evaluation in terminal oncology patients.
Int J Pharm 2006 ; 307: 278-284.
2125 Journal Gardiner PR.
Compatibility of an injectable oxycodone formulation with typical diluents, syringes, tubings, infusion bags and drugs for potential co-administration.
Hospital Pharmacist 2003 ; 10: 354-361.
2176 Journal Barcia E, Martin A, Azuara ML, Sanchez Y, Negro S.
Tramadol and hyoscine N-butyl bromide combined in infusion solutions: compatibility and stability.
Support Care Cancer 2007 ; 15: 57-62.
2900 Journal Hines S, Pleasance S.
Compatibility of an injectable high strength oxycodone formulation with typical diluents, syringes, tubings,infusion bags and drugs for potential co-administration.
EJHP 2009 ; 15, 5: 32-38.
3132 Journal Negro S, Martin A, Azuara L, Sanchez Y, Barcia E.
Compatibility and stability of ternary admixtures of tramadol, haloperidol, and hyoscine.
J Palliat Med 2010 ; 13, 3: 273-277.
4404 Poster Müller U, Haller F, Wiedemeier P, Steuer C.
Compatibility studies of seven commonly used drugs for parenteral administration in palliative care.
JFSPH 2019 2019

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