Last update :
19/11/2024
Antimuscarinic   Ipratropium bromide  
aerosol
Stability of pharmaceutical preparations Stability of mixtures Factors which affect stability Compatibility References pdf
   Chemical structure  

aerosol
Stability of mixtures   aerosol   Stability of mixtures : Ipratropium bromide     
Container excipient Compound Temperature Storage Duration of stability References
Glass
None
aerosol   Ipratropium bromide liquid125 µg/ml  Atrovent®
aerosol   Salbutamol sulfate liquid2,5 mg/ml  Ventoline®
22°C
5 Day
With or without light 2685
Glass
NaCl 0.9%
aerosol   Ipratropium bromide liquid11 µg/ml  Atrovent®
aerosol   Salbutamol sulfate liquid55 µg/ml  Sultanol®
25°C
5 Hour
Light 2770
Glass
aerosol   Ipratropium bromide Commercial Drug product0,5 mg/2,5mL  
aerosol   Formoterol fumarate Commercial Drug product20 µg/2mL  
25°C
1 Hour
Not specified 3498
Glass
None
aerosol   Ipratropium bromide liquid11 µg/ml  Atrovent®
aerosol   Fluticasone liquid20 µg/ml  Flutide®
aerosol   Salbutamol sulfate liquid55 µg/ml  Sultanol®
25°C
5 Hour
Not specified 2790
Glass
None
aerosol   Ipratropium bromide liquid125 µg/ml  Atrovent®
aerosol   Salbutamol sulfate liquid2,5 mg/ml  Ventoline®
4°C
5 Day
Protect from light 2685
Glass
Ethanol 0.45 ml
Purified water 2.55 ml
hydrochloric acid >> pH 4
aerosol   Ipratropium bromide powder0,5 mg  Ipratropium bromide
aerosol   Salbutamol sulfate powder2,5 mg  Albuterol
aerosol   Cromoglycate sodium powder20 mg  Cromolyn sodium
aerosol   Budesonide powder0,25 mg  budesonide
4°C
56 Day
Protect from light 665
Polypropylene and polyethylene
None
aerosol   Ipratropium bromide liquid0.090 mg/ml  ®=? (Nephrom Pharm)
aerosol   Levalbuterol liquid0.22 mg/ml  Xopenex®
25°C
28 Day
Not specified 2635
Not specified
None
aerosol   Ipratropium bromide liquid0.16 mg/ml  ®=? Ipratropium bromide Dey®
aerosol   Levalbuterol liquid0.41 mg/ml  ®=? Levalbuterol Sepracor®
21-25°C
0.5 Hour
Light 2803
Not specified
None
aerosol   Ipratropium bromide liquid0.20 mg/mL  Atrovent®
aerosol   Budesonide liquid0.23 mg/mL  Pulmicort®
23-26°C
0.5 Hour
Light 2774
Not specified
None
aerosol   Ipratropium bromide liquid0.20mg/mL  Atrovent®
aerosol   Budesonide liquid0.48mg/mL  Pulmicort®
23-26°C
0.5 Hour
Light 2774
Not specified
aerosol   Ipratropium bromide Commercial Drug product0,5 mg/2,5 ml  Atrovent®
aerosol   Arformoterol Commercial Drug product15 µg/2 ml  Brovana®
25°C
0.5 Hour
Light 3019
Not specified
None
aerosol   Ipratropium bromide liquid104 µg/ml  Atrovent®
aerosol   N-acetylcysteine liquid90 mg/ml  Acetein®
25°C
1 Hour
Not specified 2787

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