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19/11/2024
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Anticancer drug   Bevacizumab  
injection
Eye-drops
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Altuzan Turkey
Alymsis France
Avastin Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Japan, Luxembourg, Malaysia, Mexico, Morocco, Netherlands, New Zealand, Norway, Peru, Poland, Portugal, Romania, Spain, Sweden, Switzerland, Tunisia, United Arab Emirates, United States of America, Venezuela
Aybintio France
Bevax Argentina
Zyrabev France
Stability in solutions   injection   Stability in solutions : Bevacizumab     
Container Solvent Concentration Temperature Storage Duration of stability References
Glass None 25 mg/ml 20-25°C Protect from light
15 Day
4714
Level of evidence A+ 		Biosimilar
Glass None 25 mg/ml 22-28°C Protect from light
15 Day
4745
Level of evidence A+
Glass None 25 mg/ml 28-32°C Protect from light
30 Day
4525
Level of evidence A+ 		Biosimilar
partially used vials None 25 mg/ml 2-8°C Protect from light
72 Hour
4525
Level of evidence A+ 		Biosimilar
partially used vials None 25 mg/ml 2-8°C Protect from light
35 Day
4744
Level of evidence A+ 		Biosimilar
partially used vials None 25 mg/ml 2-8°C Protect from light
60 Day
4745
Level of evidence A+
partially used vials None 25 mg/ml 4°C Protect from light
60 Day
4714
Level of evidence A+ 		Biosimilar
Polyvinyl chloride Sodium chloride 0,9% 1,4 & 16,5 mg/ml 2-8°C Not specified
42 Day
4756
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 1,4 >>16,5 mg/ml 2-8°C Not specified
35 Day
4516
Level of evidence A+ 		Biosimilar
Polyvinyl chloride Sodium chloride 0,9% 1,4 >>16,5 mg/ml 30°C Light
2 Day
4516
Level of evidence A+ 		Biosimilar
Polyvinyl chloride Sodium chloride 0,9% 1.4 >> 16.5 mg/ml 2-30°C Not specified
48 Hour
4467
Manufacturer's stability data
Polyvinyl chloride Sodium chloride 0,9% 1.4 >> 16.5 mg/ml 2-8°C Not specified
30 Day
4467
Manufacturer's stability data
Polyolefine Sodium chloride 0,9% 1,4 & 16,5 mg/ml 2-8°C Protect from light
90 Day
4745
Level of evidence A+
Polyolefine Sodium chloride 0,9% 1,4 & 16,5 mg/ml 2-8°C Not specified
42 Day
4756
Level of evidence A+
Polyolefine Sodium chloride 0,9% 1,4 & 16,5 mg/ml 22-28°C Protect from light
3 Day
4745
Level of evidence A+
Polyolefine Sodium chloride 0,9% 1,4 & 16,5 mg/ml 25°C Not specified
3 Day
4714
Level of evidence A+ 		Biosimilar
Polyolefine Sodium chloride 0,9% 1,4 & 16,5 mg/ml 4°C Protect from light
90 Day
4714
Level of evidence A+ 		Biosimilar
Polyolefine Sodium chloride 0,9% 1,4 & 16.5 mg/ml 2-8°C Protect from light
45 Day
4525
Level of evidence A+ 		Biosimilar
Polyolefine Sodium chloride 0,9% 1,4 & 16.5 mg/ml 28-32°C Protect from light
3 Day
4525
Level of evidence A+ 		Biosimilar
Polyolefine Sodium chloride 0,9% 1,4 >>16,5 mg/ml 2-8°C Not specified
35 Day
4516
Level of evidence A+ 		Biosimilar
Polyolefine Sodium chloride 0,9% 1,4 >>16,5 mg/ml 30°C Light
2 Day
4516
Level of evidence A+ 		Biosimilar
Polyolefine Sodium chloride 0,9% 1.4 >> 16.5 mg/ml 2-30°C Not specified
48 Hour
4467
Manufacturer's stability data
Polyolefine Sodium chloride 0,9% 1.4 >> 16.5 mg/ml 2-8°C Not specified
30 Day
4467
Manufacturer's stability data
Polyolefine Sodium chloride 0,9% 16 mg/ml 22°C Not specified
90 Day
2882
Level of evidence B+
Polyolefine Sodium chloride 0,9% 16 mg/ml 4°C Not specified
90 Day
2882
Level of evidence B+
Polyolefine Sodium chloride 0,9% 2 mg/ml 22°C Not specified
90 Day
2882
Level of evidence B+
Polyolefine Sodium chloride 0,9% 2 mg/ml 4°C Not specified
90 Day
2882
Level of evidence B+
Ethylene vinyl acetate Sodium chloride 0,9% 1,4 & 16,5 mg/ml 2-8°C Not specified
42 Day
4756
Level of evidence A+
Polypropylen Syringe None 25 mg/ml 2-8°C Not specified
180 Day
2661
Level of evidence A+
Polypropylen Syringe None 25 mg/ml 4°C With or without light
90 Day
3265
Level of evidence B+
Polypropylen Syringe None 25 mg/ml 4°C Protect from light
90 Day
3312
Level of evidence B+
Polypropylen Syringe None 25 mg/ml 4°C Protect from light
30 Day
4798
syringe polycarbonate None 25 mg/ml 2-8°C Not specified
180 Day
2661
Level of evidence A+
  Mentions Légales