Last update :
28/02/2024
References   References 4756  
Type : Journal
Web link : 10.1177/10781552221088020

Research teams : Andover - Pharmaceutical Research and Development, Pfizer Inc
Authors : Weiser S, Burns C, Zartler E.
Title : Physicochemical stability of PF-06439535 (bevacizumab-bvzr; Zirabev®), a bevacizumab biosimilar, under extended in-use conditions.
Reference : J Oncol Pharm Practice ;29, 5: 1032-1043 2022

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Protein: Size Exclusion Chromatography Protein: Dynamic Light Scattering 
Chemical stability : 
Protein: Peptide mapping
Protein: ionic chromatography
Capillary electrophoresis
Ultraviolet spectrometry
Other methods : 
PH measurement 
Comments : 
Proteins: biological activity by cell culture

List of drugs
InjectionBevacizumab Anticancer drug
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1,4 & 16,5 mg/ml 2-8°C Not specified
42 Day
Stability in solutions Polyolefine Sodium chloride 0,9% 1,4 & 16,5 mg/ml 2-8°C Not specified
42 Day
Stability in solutions Ethylene vinyl acetate Sodium chloride 0,9% 1,4 & 16,5 mg/ml 2-8°C Not specified
42 Day

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