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Anticancer drug   Bevacizumab  
injection
Eye-drops
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Altuzan Turkey
Alymsis France
Avastin Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Japan, Luxembourg, Malaysia, Mexico, Morocco, Netherlands, New Zealand, Norway, Peru, Poland, Portugal, Romania, Spain, Sweden, Switzerland, Tunisia, United Arab Emirates, United States of America, Venezuela
Aybintio France
Bevax Argentina
Zyrabev France
References   injection   References : Bevacizumab  
Type Publication
2296 Manufacturer Témocilline (Negaban®) - Résumé des caractéristiques du produit
Eumedica 2017
2661 Journal Khalili H, Sharma G, Froome A, Khaw P.T, Brocchini S.
Storage stability of bevacizumab in polycarbonate and polypropylene syringes
Eye 2015 ; 29, 6: 820-827.
2882 Poster Morand K, Paul M, Lahlou A, Blanchet B, Astier A.
Stabilité de solutions diluées de bévacizumab en fonction de la température.
SFPO Congress 2009
3265 Poster Vieillard V, Cauvin A, Roumi E, Despiau MC, Laurent M, Voytenko S, Astier A, Paul M.
Stabilité physico-chimique du bévacizumab à 25 mg/mL conservée à 4°C en seringue polypropylène.
SFPO Congress, France 2011
3312 Journal Paul M, Vieillard V, Roumi E, Cauvin A, Despiau M.C, Laurent M, Astier A.
Long-term stability of bevacizumab repackaged in 1 mL polypropylene syringes for intravitreal administration.
Ann Pharm Fr 2012 ; 70, 3: 139-154.
4467 Manufacturer Avastin - Summary of Product Characteristics
Roche Products Limited 2020
4516 Journal Seckute J, Castellanos I, Bane S.
Physicochemical stability of the bevacizumab biosimilar, ABP 215, after preparation and storage in intravenous bags.
GaBI Journal 2020 ; 9, 4:155-162
4525 Journal Park D, Kim J, Yun J, Park S.J.
Evaluation of the Physico-Chemical and Biological Stability of SB8 (Aybintio), a Proposed Biosimilar to Bevacizumab, Under Ambient and In-Use Conditions.
Adv Ther 2020 ; 37: 4308–4324.
4714 Poster Vieillard V, Paul M
Etude de stabilité d'un biosimilaire du Bevacizumab dans les flacons et après dilution dans du NaCl 0.9% en poche de polyoléfine.
GERPAC Congrès - octobre 2022 2022
4744 Manufacturer Stability Report of Extended SB8 Opened Vial (400 mg) Stability (personal communication).
Samsung laboratory 2023
4745 Journal Vieillard V, Paul M
Physicochemical stability study of a biosimilar of Bevacizumab in vials and after dilution in 0.9% NaCl in polyolefin intravenous bags.
Pharmaceutical Technology in Hospital Pharmacy 2023
4756 Journal Weiser S, Burns C, Zartler E.
Physicochemical stability of PF-06439535 (bevacizumab-bvzr; Zirabev®), a bevacizumab biosimilar, under extended in-use conditions.
J Oncol Pharm Practice 2022 ;29, 5: 1032-1043
4798 Journal Gjølberg T, Lode H, Melo G, Mester S,Probst C, Sivertsen M, Jørstad ø, Andersen J, Moe M.
A silicone Oil-Free Syringe Tailored for Intravitreal Injection of Biologics.
Frontiers in Ophthalmology 2022 ;2
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