Last update :
19/11/2024
Anticancer drug   Pemetrexed disodium  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Alimta Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Denmark, Ecuador, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Japan, Luxembourg, Malaysia, Mexico, Morocco, Netherlands, New Zealand, Norway, Peru, Poland, Portugal, Romania, Saudi Arabia, Spain, Sweden, Switzerland, Tunisia, Turkey, United Arab Emirates, United States of America, Venezuela
Alltrexed Argentina
Amtiris Switzerland
Armisarte
Ekel Argentina
Enzastar Argentina
Holista Argentina
Lidoras Argentina, Ecuador
Martxel Argentina
Pamifect India
Pemetrexed Argentina, Peru, Romania, Switzerland
Pemtrex Turkey
Peymetrel Argentina
Praxed Argentina
Prexed Turkey
Sukuba Argentina
Trexam Argentina
Trextech Argentina
Trixid Romania
Utrexed Argentina
Venusted Argentina
References   injection   References : Pemetrexed disodium  
Type Publication
1914 Manufacturer Pemetrexed (Alimta®) - Summary of Product Characteristics
Eli Lilly 2016
1953 Journal Trissel LA, Saenz CA, Ogundele AB, Ingram DS.
Physical compatibility of pemetrexed disodium with other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2004 ; 61: 2289-2293.
2036 Journal Zhang Y, Trissel LA.
Physical and chemical stability of pemetrexed solutions in plastic syringes.
Ann Pharmacotherapy 2005 ; 39, 12: 2026-2028.
2114 Journal Zhang Y, Trissel LA.
Physical and chemical stability of pemetrexed in infusion solutions.
Ann Pharmacotherapy 2006 ; 40, 6: 1082-1085.
2117 Journal Zhang Y, Trissel LA.
Physical instability of frozen pemetrexed solutions in PVC bags.
Ann Pharmacotherapy 2006 ; 40, 7: 1289-1292.
2183 Journal Rondelot G, Serrurier C, Vigneron J, Zenier H, May I, Demoré B.
Stability of pemetrexed 25 mg/ml in a glass vial and 5 mg/ml stored in a PVC container after storage for one month at 2-8°C.
EJHP Science 2007 ; 13, 1: 14-16.
4137 Journal Patel T, Sewell G.
Short Report : Extended Stability Studies on Bortezomib Injection and Infusions of Cisplatin and Pemetrexed (all Accord Healthcare).
Newsletter Stabilis 2018 41;2-6
4578 Thesis Respaud R.
Etude de stabilité de médicaments anticancéreux injectables : apports analytiques et pharmaceutiques
2011
4624 Journal Nelson L, Dwier P, Corris M, Santillo M, Davies L, Milligan K, Rahman R, Clarke I.
Stability of pemetrexed disodium in sodium chloride 0.9% w/v intravenous Viaflo infusion bags.
EJHP 2023 ; 30: e2-e9.

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