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Local anesthetic   Levobupivacaine hydrochloride  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Chirocaina Chile
Chirocaine Australia, Belgium, Brazil, Finland, Great Britain, Greece, Hungary, Ireland, Italy, Luxembourg, Malaysia, Peru, Spain, Sweden, Switzerland, Turkey, Venezuela
Levobupivacaina Spain
Levobupivacaine Belgium, France
Levocaine Peru
Stability of mixtures   Injection   Stability of mixtures : Levobupivacaine hydrochloride     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Polyvinyl chloride Sodium chloride 0,9% 1,25 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Sufentanil citrate 0,001 mg/ml
-30°C
120 Day
Protect from light 1938
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 1,25 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Sufentanil citrate 0,001 mg/ml
4°C
58 Day
Protect from light 1962
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 1,25 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Sufentanil citrate 0,001 mg/ml
4°C
70 Day
Protect from light 1938
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 1,25 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Sufentanil citrate 0,001 mg/ml
4°C
58 Day
Not specified 1908
Level of evidence A
Polypropylene Sodium chloride 0,9% 1,25 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Sufentanil citrate 0,001 mg/ml
4°C
180 Day
Not specified 4522
Level of evidence B
Polypropylen Syringe Sodium chloride 0,9% 1,22 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Sufentanil citrate 0,00113 mg/ml
21°C
28 Day
Protect from light 1835
Level of evidence D
Polypropylen Syringe Sodium chloride 0,9% 1,22 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Sufentanil citrate 0,00113 mg/ml
36°C
28 Day
Protect from light 1835
Level of evidence D
Polypropylen Syringe Sodium chloride 0,9% 1,22 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Sufentanil citrate 0,00113 mg/ml
4°C
28 Day
Protect from light 1835
Level of evidence D
Polypropylen Syringe Sodium chloride 0,9% 1,25 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Sufentanil citrate 0,001 mg/ml
4°C
180 Day
Not specified 4522
Level of evidence B
Not specified Sodium chloride 0,9% ? mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Clonidine hydrochloride 0,0084 mg/ml
20-22 °C
40 Hour
Not specified 3507
Manufacturer's stability data
Not specified Sodium chloride 0,9% ? mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Fentanyl citrate 4 µg/ml
20-22 °C
40 Hour
Not specified 3507
Manufacturer's stability data
Not specified None 0,56 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Epinephrine hydrochloride 2 µg/ml
Injection   Fentanyl citrate 4,1 µg/ml
20-24°C
40 Day
Protect from light 3401
Level of evidence D
Not specified None 0,56 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Fentanyl citrate 4,1 µg/ml
20-24°C
60 Day
With or without light 3401
Level of evidence D
Not specified None 0,56 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Epinephrine hydrochloride 2 µg/ml
Injection   Fentanyl citrate 4,1 µg/ml
20-24°C
48 Hour
Light 3401
Level of evidence D
Not specified None 0,56 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Fentanyl citrate 4,1 µg/ml
Injection   Epinephrine hydrochloride 2 µg/ml
4-8°C
60 Day
Protect from light 3401
Level of evidence D
Not specified None 0,56 mg/ml
Injection   Levobupivacaine hydrochloride   
Injection   Fentanyl citrate 4,1 µg/ml
4-8°C
60 Day
Protect from light 3401
Level of evidence D
  Mentions Légales