Last update :
19/04/2021
References   References 4522  
Type : Journal

Research teams : Louvain - Laboratory for Pharmaceutical Chemistry and Drug Analysis
Authors : Lin Q, Van Schepdael A, Adams E.
Title : Six months stability investigation of sufentanil and ropivacaine/levobupivacaine admixtures in plastic container by LC-UV.
Reference : J Pharm Biomed Anal 2020

Level of Evidence : 
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement Measurement of osmolality 
Comments : 

List of drugs
InjectionLevobupivacaine hydrochloride Local anesthetic
InjectionRopivacain hydrochloride Local anesthetic
InjectionSufentanil citrate Analgesic
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 4°C Not specified
Injection Ropivacain hydrochloride 1,2 mg/ml
Injection Sufentanil citrate 0,00075 mg/ml
180 Day
Polypropylene Sodium chloride 0,9% 4°C Not specified
Injection Sufentanil citrate 0,001 mg/ml
Injection Levobupivacaine hydrochloride 1,25 mg/ml
180 Day
Polypropylen Syringe Sodium chloride 0,9% 4°C Not specified
Injection Sufentanil citrate 0,001 mg/ml
Injection Levobupivacaine hydrochloride 1,25 mg/ml
180 Day
Polypropylen Syringe Sodium chloride 0,9% 4°C Not specified
Injection Sufentanil citrate 0,00075 mg/ml
Injection Ropivacain hydrochloride 1,2 mg/ml
180 Day

  Mentions Légales