Last update :
19/11/2024
Local anesthetic   Levobupivacaine hydrochloride  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Chirocaina Chile
Chirocaine Australia, Belgium, Brazil, Finland, Great Britain, Greece, Hungary, Ireland, Italy, Luxembourg, Malaysia, Peru, Spain, Sweden, Switzerland, Turkey, Venezuela
Levobupivacaina Spain
Levobupivacaine Belgium, France
Levocaine Peru
References   injection   References : Levobupivacaine hydrochloride  
Type Publication
1835 Journal Jäppinen A, Turpeinen M, Kokki H, ,Rasi A, Ojanen T, Pelkonen O, Naaranlahti T.
Stability of sufentanil and levobupivacain solutions and a mixture in a 0.9% sodium chloride infusion stored in polypropylene syringes.
Eur J Pharm Sci 2003 ; 19, 1: 31-36.
1908 Journal Boitquin L, Hecq JD, Evrard JM, Vanbeckbergen D, Jamart J, Galanti L.
Long-term stability of sufentanil citrate with levobupivacaine hydrochloride in 0.9% sodium chloride infusion PVC bags at 4°C.
J Pain Symptom Manage 2004 ; 28, 1: 4-6.
1938 Journal Boitquin LP, Hecq JD, Vanbeckbergen DF, Jamart J, Galanti LM.
Stability of sufentanil citrate with levobupivacaine hydrochloride in NaCl 0.9% after microwave freeze-thaw treatment.
Ann Pharmacotherapy 2004 ; 38: 1836-1839.
1962 Journal Hecq JD, Boitquin L, Evrard JM, Vanbeckbergen D, Jamart J, Galanti L.
Long term stability of sufentanyl citrate with levobupivacaine hydrochloride in 0.9% sodium chloride infusion P.V.C bags at 4°C.
Pharmakon 2004 ; 36, 1: 8-14.
2225 Journal Sacco R, Sacchetto G, Francalanci M, Boselli C.
Studio di stabilità chimico-fisica di una formulazione per la terapia antalgica a base di levobupivacaina e fentanyl.
Bolletino SIFO 2006 ; 77:81
3184 Manufacturer
Hyaluronidase (Hyalase®) - Summary of Product characteristics.
CP Pharmaceuticals 2005
3372 Journal Hanci V, Ali Kiraz H, Ömür D, Ekin S, Uyan B, Yurtlu B.S.
Precipitation in Gallipoli: Sugammadex / Amiodarone & Sugammadex / Dobutamine & Sugammadex / Protamine.
Rev Bras Anestesiol 2013 ; 63, 1: 163-166.
3401 Journal Helin-Tanninen, M., Lehtonen, M., Naaranlahti, T., Ven?l?inen, T., Pentik?inen, J., Laatikainen, A., Kokki, H.
Stability of an epidural analgesic admixture of levobupivacaine, fentanyl and epinephrine.
J Clin Pharm Ther 2013 ;38, 2: 104-108
3507 Manufacturer Chirocaine - Summary of Product Characteristics
AbbVie 2013
4522 Journal Lin Q, Van Schepdael A, Adams E.
Six months stability investigation of sufentanil and ropivacaine/levobupivacaine admixtures in plastic container by LC-UV.
J Pharm Biomed Anal 2020

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