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Anticancer drug   Topotecan  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Acumil Mexico
Camtoop Mexico
Cantop India
Hycamtin Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Denmark, Ecuador, Egypt, Finland, France, Germany, Great Britain, Greece, Hungary, Iceland, Ireland, Italy, Japan, Luxembourg, Malaysia, Netherlands, Norway, Poland, Portugal, Saudi Arabia, Spain, Sweden, Switzerland, Turkey, United Arab Emirates, United States of America, Venezuela
Oncotecan Colombia, Ecuador
Potactasol Argentina, Belgium, Germany, Norway, Romania
Tekan L Turkey
Topodria Colombia
Topokebir Argentina, Peru
Toposec Peru
Topotecan Belgium, Canada, Colombia, Germany, Great Britain, Norway, Peru, Romania, Spain
Topotel Egypt
Toranex Mexico
Tpopoxin Turkey
Viatopin Hungary
Stability in solutions   injection   Stability in solutions : Topotecan     
Container Solvent Concentration Temperature Storage Duration of stability References
Glass Water for Injection 1 mg/ml 2-8°C Not specified
48 Hour
753
Manufacturer's stability data
Glass Water for Injection 1 mg/ml 2-8°C Protect from light
28 Day
1425
Level of evidence A
Glass Water for Injection 1 mg/ml 25°C Not specified
48 Hour
753
Manufacturer's stability data
Glass Water for Injection 1 mg/ml 25°C Not specified
28 Day
1274
Level of evidence D
Glass Water for Injection 1 mg/ml 25°C Protect from light
28 Day
1425
Level of evidence A
Glass Water for Injection 1 mg/ml 4°C Protect from light
28 Day
1274
Level of evidence D
Glass Water for Injection 1 mg/ml 5°C Protect from light
28 Day
823
Level of evidence A
Glass NaCl 0,9% or Glucose 5% 0,05 mg/ml 23-24°C Light
24 Hour
1075
Level of evidence B
Glass NaCl 0,9% or Glucose 5% 0,05 mg/ml 5°C Protect from light
7 Day
1075
Level of evidence B
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 2-8°C Protect from light
28 Day
1425
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 25°C Protect from light
28 Day
1425
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,025 mg/ml 23°C-24°C Light
24 Hour
1075
Level of evidence B
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,025 mg/ml 5°C Protect from light
7 Day
1075
Level of evidence B
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,05 mg/ml 23-24°C Light
24 Hour
1075
Level of evidence B
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,05 mg/ml 5°C Protect from light
7 Day
1075
Level of evidence B
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,05 & 0,025 mg/ml 25°C Protect from light
28 Day
1274
Level of evidence D
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,05 & 0,025 mg/ml 4°C Protect from light
28 Day
1274
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 0,01 mg/ml 25°C Light
7 Day
1274
Level of evidence D
Polyolefine NaCl 0,9% or Glucose 5% 0,05 mg/ml 23-24°C Light
24 Hour
1075
Level of evidence B
Polyolefine NaCl 0,9% or Glucose 5% 0,05 mg/ml 5°C Protect from light
7 Day
1075
Level of evidence B
Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,01 & 0,05 mg/ml 25°C Protect from light
21 Day
1274
Level of evidence D
Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,01 & 0,05 mg/ml 4°C Protect from light
21 Day
1274
Level of evidence D
Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 2-8°C Protect from light
28 Day
1425
Level of evidence A
Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 25°C Protect from light
28 Day
1425
Level of evidence A
  Mentions Légales