Last update :
29/10/2024
Analgesic   Methadone hydrochloride  
injection
Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Eptadone Italy
Ketalgin Switzerland
Mephenon Belgium
Metasedin Spain
Methadone
Physeptone Great Britain
Compatibility   injection   Compatibility : Methadone hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Atropine sulfate 0.4 mg/ml
Glucose 5% 1974
Compatible
injection Methadone hydrochloride 0.2 mg/ml
injection Clonidine hydrochloride 0.0075 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Dexamethasone sodium phosphate 1 mg/ml
Glucose 5% 1974
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Diazepam 0.5 mg/ml
Glucose 5% 1974
Immediate precipitation Incompatible
injection Methadone hydrochloride
injection Diclofenac
Sodium chloride 0,9% 3470
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Diphenhydramine hydrochloride 2 mg/ml
Glucose 5% 1974
Compatible
injection Methadone hydrochloride 0.2 mg/ml
injection Dobutamine hydrochloride 8 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
injection Methadone hydrochloride 0.2 mg/ml
injection Dopamine hydrochloride 8 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
injection Methadone hydrochloride 0.2 mg/ml
injection Esomeprazole sodium 0.32 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
injection Methadone hydrochloride 0.2 mg/ml
injection Furosemide 2 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Haloperidol lactate 0.2 mg/ml
Glucose 5% 1974
Compatible
injection Methadone hydrochloride 0.2 mg/ml
injection Heparin sodium 50 UI/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Hydroxyzine dihydrochloride 4 mg/ml
Glucose 5% 1974
Compatible
injection Methadone hydrochloride 0.2 mg/ml
injection Insulin 1 UI/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
injection Methadone hydrochloride 0.59 >> 2.94 mg/ml
injection Ketorolac tromethamine 1.76 >> 5.29 mg/ml
Sodium chloride 0,9% 3470
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Ketorolac tromethamine 1 mg/ml
Glucose 5% 1974
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Lorazepam 0.1 mg/ml
Glucose 5% 1974
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Metoclopramide hydrochloride 5 mg/ml
Glucose 5% 1974
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Midazolam hydrochloride 0.2 mg/ml
Glucose 5% 1974
Compatible
injection Methadone hydrochloride 0.2 mg/ml
injection Midazolam hydrochloride 4 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
injection Methadone hydrochloride 0.2 mg/ml
injection Norepinephrine bitartrate 0.32 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
injection Methadone hydrochloride 0.2 mg/ml
injection Pantoprazole sodium 0.32 mg/ml
NaCl 0,9% or Glucose 5% 1506
Unspecified incompatibility Incompatible
injection Methadone hydrochloride
injection Parecoxib sodium
3504
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Phenobarbital sodium 2 mg/ml
Glucose 5% 1974
Immediate precipitation Incompatible
injection Methadone hydrochloride 1 mg/ml
injection Phenytoin sodium 2 mg/ml
Glucose 5% 1974
Compatible
injection Methadone hydrochloride 1 mg/ml
injection Scopolamine hydrobromide 0.05 mg/ml
Glucose 5% 1974

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