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Analgesic   Tramadol hydrochloride  
injection
Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Acugesic Malaysia
Adolonta Spain
Amadol Egypt
Analgon Peru
Contramal Belgium, France, Hungary, Italy, Turkey
Eufindol Chile
Fortradol Italy
Lafedol Argentina
Liochta Mexico
Mabron Malaysia, Romania, Spain
Megadol Chile, Colombia
Nobligan Denmark
Paxilfar Portugal
Poltram Poland
Prontalgin Italy
Sylador Saudi Arabia
Tadol Slovenia
Topalgic France
Trabilin Malaysia, Saudi Arabia
Tradolan Austria, Denmark, Iceland, Sweden
Tradonal Belgium, Luxembourg
Tramabene Austria
Tramadolor Austria, Croatia, Germany
Tramagetic Germany, Netherlands
Tramal Argentina, Brazil, Colombia, Ecuador, Egypt, Finland, Germany, Iran, Luxembourg, Netherlands, New Zealand, Peru, Poland, Portugal, Saudi Arabia, Slovenia, Switzerland, Tunisia, United Arab Emirates, Venezuela
Tramastad Austria
Zamadol Great Britain, India
Zydol Great Britain
Stability of mixtures   injection   Stability of mixtures : Tramadol hydrochloride     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Glass Sodium chloride 0,9% 0,97 mg/ml
injection   Tramadol hydrochloride   
injection   Ketoprofene 0,95 mg/ml
20-24°C
24 Hour
Light 3075
Glass None 0,94 mg/ml
injection   Tramadol hydrochloride   
injection   Paracetamol 9,44 mg/ml
20-24°C
24 Hour
Light 3075
Glass None 0,96 mg/ml
injection   Tramadol hydrochloride   
injection   Paracetamol 10,04 mg/ml
injection   Ketoprofene 0,96 mg/ml
20-24°C
24 Hour
Light 3075
Polyvinyl chloride Sodium chloride 0,9% 20 mg/ml
injection   Tramadol hydrochloride   
injection   Ketorolac tromethamine 2 mg/ml
25°C
7 Day
Light 3159
Level of evidence D
Polyethylene Glucose 5% 1 mg/ml
injection   Tramadol hydrochloride   
injection   Droperidol 0,025 mg/ml
2-8°C
32 Day
Protect from light 2814
Level of evidence A
Polyethylene Glucose 5% 0,82 mg/ml
injection   Tramadol hydrochloride   
injection   Alizapride hydrochloride 0,41 mg/ml
2-8°C
32 Day
Not specified 3115
Level of evidence C
Polyethylene Glucose 5% 1 mg/ml
injection   Tramadol hydrochloride   
injection   Metoclopramide hydrochloride 0,1 mg/ml
4°C
32 Day
Protect from light 3082
Level of evidence A+
Polypropylene Sodium chloride 0,9% 8.33>>33.33 mg/ml
injection   Tramadol hydrochloride   
injection   Dexamethasone sodium phosphate 0.33>>3.33 mg/ml
25°C
5 Day
Protect from light 2211
Level of evidence A+
Polypropylene Sodium chloride 0,9% 8,33 mg/ml
injection   Tramadol hydrochloride   
injection   Haloperidol lactate 0,208 mg/ml
25°C
15 Day
Protect from light 2024
Level of evidence C+
Polypropylene Sodium chloride 0,9% 33,33 mg/ml
injection   Tramadol hydrochloride   
injection   Haloperidol lactate 0,625 mg/ml
25°C
15 Day
Protect from light 2024
Level of evidence C+
Polypropylene Sodium chloride 0,9% 8,33>>33,3 mg/ml
injection   Tramadol hydrochloride   
injection   Scopolamine N-butyl bromide 3,33>>6,67 mg/ml
25°C
15 Day
Protect from light 2176
Level of evidence B
Polypropylene Sodium chloride 0,9% 8,33 mg/ml
injection   Tramadol hydrochloride   
injection   Haloperidol lactate 0,208 mg/ml
4°C
15 Day
Protect from light 2024
Level of evidence C+
Polypropylene Sodium chloride 0,9% 33,33 mg/ml
injection   Tramadol hydrochloride   
injection   Haloperidol lactate 0,625 mg/ml
4°C
15 Day
Protect from light 2024
Level of evidence C+
Polypropylene Sodium chloride 0,9% 8,33>>33,3 mg/ml
injection   Tramadol hydrochloride   
injection   Scopolamine N-butyl bromide 3,33>>6,67 mg/ml
4°C
15 Day
Protect from light 2176
Level of evidence B
Polypropylene None 33,3 mg/ml
injection   Tramadol hydrochloride   
injection   Ketorolac tromethamine 10 mg/ml
25°C
7 Day
3159
Level of evidence D
Polyolefine NaCl 0,9% or Glucose 5% 5 mg/ml
injection   Tramadol hydrochloride   
injection   Dexketoprofen 2,5 mg/ml
injection   Haloperidol lactate 0,05 mg/ml
- 20°C
30 Day
Protect from light 3297
Level of evidence C
Polyolefine NaCl 0,9% or Glucose 5% 5 mg/ml
injection   Tramadol hydrochloride   
injection   Dexketoprofen 2,5 mg/ml
injection   Haloperidol lactate 0,05 mg/ml
25°C
30 Day
With or without light 3297
Level of evidence C
Polyolefine NaCl 0,9% or Glucose 5% 5 mg/ml
injection   Tramadol hydrochloride   
injection   Dexketoprofen 2,5 mg/ml
injection   Haloperidol lactate 0,05 mg/ml
4°C
30 Day
Protect from light 3297
Level of evidence C
Polyolefine Sodium chloride 0,9% 4 mg/ml
injection   Tramadol hydrochloride   
injection   Bupivacaine hydrochloride 1,2 mg/ml
25°C
15 Day
With or without light 3296
Level of evidence C
Polyolefine Sodium chloride 0,9% 4 mg/ml
injection   Tramadol hydrochloride   
injection   Ropivacain hydrochloride 2 mg/ml
25°C
15 Day
With or without light 3296
Level of evidence C
Polyolefine Sodium chloride 0,9% 10 mg/ml
injection   Tramadol hydrochloride   
injection   Ondansetron hydrochloride 0,08 mg/ml
25°C
14 Day
Not specified 4116
Level of evidence A
Polyolefine Sodium chloride 0,9% 10 mg/ml
injection   Tramadol hydrochloride   
injection   Granisetron hydrochloride 0,06 mg/ml
25°C
14 Day
Not specified 4116
Level of evidence A
Polyolefine Sodium chloride 0,9% 10 mg/ml
injection   Tramadol hydrochloride   
injection   Tropisetron hydrochloride 0,05 mg/ml
25°C
14 Day
Not specified 4116
Level of evidence A
Polyolefine Sodium chloride 0,9% 4 mg/ml
injection   Tramadol hydrochloride   
injection   Bupivacaine hydrochloride 1,2 mg/ml
4°C
15 Day
Protect from light 3296
Level of evidence C
Polyolefine Sodium chloride 0,9% 4 mg/ml
injection   Tramadol hydrochloride   
injection   Ropivacain hydrochloride 2 mg/ml
4°C
15 Day
Protect from light 3296
Level of evidence C
Polyolefine Sodium chloride 0,9% 10 mg/ml
injection   Tramadol hydrochloride   
injection   Ondansetron hydrochloride 0,08 mg/ml
4°C
14 Day
Not specified 4116
Level of evidence A
Polyolefine Sodium chloride 0,9% 10 mg/ml
injection   Tramadol hydrochloride   
injection   Granisetron hydrochloride 0,06 mg/ml
4°C
14 Day
Not specified 4116
Level of evidence A
Polyolefine Sodium chloride 0,9% 10 mg/ml
injection   Tramadol hydrochloride   
injection   Tropisetron hydrochloride 0,05 mg/ml
4°C
14 Day
Not specified 4116
Level of evidence A
Not specified Sodium chloride 0,9% 8,8 >> 33,3 mg/ml
injection   Tramadol hydrochloride   
injection   Scopolamine N-butyl bromide 3,33 >> 6,67 mg/ml
injection   Haloperidol lactate 0,208 >> 0,624 mg/ml
25°C
15 Day
Protect from light 3132
Level of evidence C+
  Mentions Légales