Last update :
08/05/2024
Anti-inflammatory   Ketorolac tromethamine  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Bedoral Republic of South Africa
Ketorolac trometamol Great Britain
Lixidol Italy
Taradyl Belgium
Toradol Denmark, Finland, Great Britain, Italy, Norway, Spain, Sweden
References   Injection   References : Ketorolac tromethamine  
Type Publication
59 Journal Trissel LA, Gilbert DL, Martinez JF, Kim MC.
Compatibility of remifentanil hydrochloride with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 2192-2196.
216 Journal Huang E, Anderson RP.
Compatibility of hydromorphone hydrochloride with haloperidol lactate and ketorolac tromethamine.
Am J Hosp Pharm 1994 ; 51: 2963.
228 Journal Mendenhall A, Hoyt DB.
Incompatibility of ketorolac tromethamine with haloperidol lactate and triethylperazine maleate.
Am J Hosp Pharm 1994 ; 51: 2964.
299 Journal Trissel LA, Martinez JF, Gilbert DL.
Compatibility of cisatracurium besylate with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1735-1741.
451 Journal Das Gupta V, Maswoswe J, Bailey RE.
Stability of ketorolac tromethamine in 5% dextrose injection and 0.9% sodium chloride injections.
Int J Pharm Compound 1997 ; 1: 206-207.
469 Journal Floy BJ, Royko CJ, Fleitman JS.
Compatibility of ketorolac tromethamine injection with common infusion fluids and administration sets.
Am J Hosp Pharm 1990 ; 47: 1097-1100.
476 Journal Knapp AJ, Mauro VF, Alexander KS.
Incompatibility of ketorolac tromethamine with selected postoperative drugs.
Am J Hosp Pharm 1992 ; 49: 2960-2962.
1634 Journal Shi A, Walker SE, Law S.
Stability of ketorolac tromethamine in IV solutions and waste reduction.
Can J Hosp Pharm 2000 ; 53: 263-269.
1712 Journal Trissel LA, Saenz CA.
Compatibility screening of Precedex during simulated Y-site administration with other drugs.
Int J Pharm Compound 2002 ; 6: 230-233.
1721 Journal Trissel LA, Williams KY, Baker MB.
Compatibility screening of Hextend during simulated Y-site administration with other drugs.
Int J Pharm Compound 2001 ; 5: 69-72.
1800 Journal Voytilla KL, Tyler LS, Rusho WJ.
Visual compatibility of azithromycin with 24 commonly used drugs during simulated Y-site delivery.
Am J Health-Syst Pharm 2002 ; 59: 853-855.
1803 Journal Trissel, LA, Saenz CA, Ogundele OB, Ingram D, Baker MB.
Compatibility of fenoldopam mesylate with other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2003 ; 60: 80-85.
1859 Journal Anacardio R, Perilli O, Pagnanelli F, Bartolini S, gentile MM, Mazzeo P, Carlucci G.
Physicochemical compatibility between thiocolchicoside injections (Miotens®) and pharmaceutical products frequently used for combined therapy.
Il Farmaco 2002 ; 57: 925-930.
1974 Journal Chandler SW, Trissel LA, Weinstein SM
Combined administration of opoids with selected drugs to manage pain and other cancer symptoms initial safety screening for compatibility.
J Pain Symptom Manage 1996 ; 12, 3: 168-171.
2015 Journal Hecq JD, Boitquin LP, Vanbeckbergen DF, Jamart J, Galanti LM.
Effect of freezing, long term storage, and microwave thawing on the stability of ketorolac tromathamine.
Ann Pharmacotherapy 2005 39: 1654-1658.
2124 Journal Hecq JD, Boitquin L, Lebrun C, Vanbeckbergen D, Evrard JM, Jamart J, Galanti L.
Freeze thaw treatment of ketorolac tromethamine in 5% dextrose infusion polyolein bags: effect of drug concentration and microwave power on the long-term stability at 4°C.
EJHP Science 2006 ; 12, 4: 72-75.
2166 Journal Nassr S, Dubuc MC, Lavoie P, Brazier JL.
HPLC-DAD methods for studying the stability of solutions containing hydromorphone, ketorolac, haloperidol, midazolam, famotidine, metoclopramide, dimenhydrinate and scopolamine.
J Liquid Chrom Rel Technol 2003 ; 26, 17: 2909-2929.
3159 Journal Lin, T.-F., Lin, F.-S., Chou, W.-H., Yeh, Y.-C., Lin, C.-P., Fan, S.-Z., Sun, W.-Z.
Compatibility and stability of binary mixtures of ketorolac tromethamine and tramadol hydrochloride injection concentrate and diluted infusion solution.
Acta Anaesthesiol Taiwan 2010 ; 48, 3 : 117-121.
3169 Journal Raffaeli W, Pari G, Visani L et al.
Experimentation about precipitation of pharmacological association: morphine and ketorolac.
Pain Clinic 1999 ; 11: 213-216.
3374 Journal Smith R.P.R, Jones M.
Precipitation in Manchester: ketorolac/cyclizine
Anaesthesia 2001 ; 56: 494-495.
3470 Journal Destro M, Ottolini L, Vicentini L, Boschetti S.
Physical compatibility of binary and tertiary mixtures of morphine and methadone with other drugs for parenteral administration in palliative care.
Support Care Cancer 2012 ; 20: 2501-2509.
3571 Journal Anderson C, Boehme S, Ouellette J, Stidham C, MacKay M.
Physical and Chemical Compatibility of Injectable Acetaminophen During Simulated Y-Site Administration.
Hosp Pharm 2014 ; 49, 1: 42-47.
3593 Manufacturer Ketorolac trometamol (Ketorolac®) - Summary of Product Characteristics
Beacon Pharmaceuticals 2011
3601 Manufacturer Cisatracurium Actavis - Résumé des Caractéristiques du Produit
Actavis 2012
4433 Journal Ghazi I.M, El Nekidy W.S, Sood A, Dulku A, Patel R, Patel K.
Y-site Administration of Imipenem/Cilastatin/ Relebactam With Common Intravenous Medications
Clin Ther 2020 ; 42, 3: 475-485.
4435 Journal Hanifah S, Nugroho B.H, Chabib L.
Compatibility of acetaminophen with central nervous system medications during simulated Y-site injection.
Anaesthesiol Intensive Ther 2020 ; 52, 1: 23-27.

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