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Sympathomimetic   Epinephrine hydrochloride  
injection
Ointments
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Adrenalin Canada, Denmark, Finland, Germany, Iceland, Luxembourg, Norway, Spain, Sweden, Switzerland, Turkey
Adrenalina Argentina, Colombia, Portugal, Romania, Spain
Adrenaline Egypt, France, New Zealand, Saudi Arabia
Anapen Austria, France, Germany, Great Britain, Netherlands, Sweden, Switzerland
Emerade Germany, Romania
Epipen Argentina, Austria, Belgium, Canada, Denmark, Finland, Great Britain, Netherlands, New Zealand, Norway, Sweden, Switzerland, United States of America
L - Adrenalin Austria
Levophed Greece
Levopress Venezuela
Min I Ject Adrenalin Great Britain
Pinadrina Mexico
Suprarenin Austria, Germany
Tonogen Hungary
Vasocon India
Stability of mixtures   injection   Stability of mixtures : Epinephrine hydrochloride     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Glass NaCl 0,9% or Glucose 5% 2 & 100 µg/ml
injection   Epinephrine hydrochloride   
injection   Tirofiban 50 µg/ml
20°C-25°C
4 Hour
Light 1603
Level of evidence A+
Glass NaCl 0,9% or Glucose 5% 0,1 µg/ml
injection   Epinephrine hydrochloride   
injection   Cefpirome sulfate 50 mg/ml
23°C
8 Hour
Protect from light 280
Level of evidence B+
Glass Glucose 5% 0,03 µg/ml
injection   Epinephrine hydrochloride   
injection   Milrinone lactate 0,2 mg/ml
22°C-23°C
4 Hour
Light 813
Level of evidence A
Glass Ringer’s lactate solution 0,1 µg/ml
injection   Epinephrine hydrochloride   
injection   Cefpirome sulfate 50 mg/ml
23°C
8 Hour
Protect from light 280
Level of evidence B+
Glass Sodium chloride 0,45% 0,1 µg/ml
injection   Epinephrine hydrochloride   
injection   Cefpirome sulfate 50 mg/ml
23°C
8 Hour
Protect from light 280
Level of evidence B+
Polyvinyl chloride Sodium chloride 0,9% 0,0006 µg/ml
injection   Epinephrine hydrochloride   
injection   Bupivacaine hydrochloride 0,43 mg/ml
injection   Fentanyl citrate 1,25 µg/ml
30°C
48 Hour
Protect from light 217
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 0,0006 µg/ml
injection   Epinephrine hydrochloride   
injection   Bupivacaine hydrochloride 0,43 mg/ml
injection   Fentanyl citrate 1,25 µg/ml
3°C
20 Day
Protect from light 217
Level of evidence C
Polyvinyl chloride Not specified 2 µg/ml
injection   Epinephrine hydrochloride   
injection   Fentanyl citrate 2 µg/ml
injection   Bupivacaine hydrochloride 1 mg/ml
18-22°C
184 Day
Protect from light 2306
Level of evidence B
Polyvinyl chloride Not specified 2 µg/ml
injection   Epinephrine hydrochloride   
injection   Bupivacaine hydrochloride 1 mg/ml
injection   Fentanyl citrate 2 µg/ml
4°C
184 Day
Protect from light 2306
Level of evidence B
Polypropylene Sodium chloride 0,9% 3,5 µg/ml
injection   Epinephrine hydrochloride   
injection   Lidocaine hydrochloride 3,5 mg/ml
injection   Bleomycin sulfate 0,75 mg/ml
22°C
1 Day
Not specified 3420
Level of evidence A
Polypropylene Sodium chloride 0,9% 3,5 µg/ml
injection   Epinephrine hydrochloride   
injection   Lidocaine hydrochloride 3,5 mg/ml
injection   Bleomycin sulfate 0,75 mg/ml
4°C
3 Day
Not specified 3420
Level of evidence A
Polypropylene None 2 µg/ml
injection   Epinephrine hydrochloride   
injection   Fentanyl citrate 2 µg/ml
injection   Bupivacaine hydrochloride 1 mg/ml
22°C
180 Day
Light 1875
Level of evidence B
Polypropylene None 9 µg/ml
injection   Epinephrine hydrochloride   
injection   Lidocaine hydrochloride 9 mg/ml
injection   Sodium bicarbonate 7,8 mg/ml
4-7°C
7 Day
Protect from light 2878
Level of evidence B
Polypropylene None 9 µg/ml
injection   Epinephrine hydrochloride   
injection   Lidocaine hydrochloride 18 mg/ml
injection   Sodium bicarbonate 7,8 mg/ml
4-7°C
7 Day
Protect from light 2878
Level of evidence B
Polypropylene None 2 µg/ml
injection   Epinephrine hydrochloride   
injection   Fentanyl citrate 2 µg/ml
injection   Bupivacaine hydrochloride 1 mg/ml
4°C
180 Day
Protect from light 1875
Level of evidence B
Not specified Sodium chloride 0,9% 32 µg/ml
injection   Epinephrine hydrochloride   
injection   Calcium chloride 4 mg/ml
25°C
26 Hour
With or without light 3622
Level of evidence A+
Not specified None 2 µg/ml
injection   Epinephrine hydrochloride   
injection   Fentanyl citrate 4,1 µg/ml
injection   Levobupivacaine hydrochloride 0,56 mg/ml
20-24°C
40 Day
Protect from light 3401
Level of evidence D
Not specified None 2 µg/ml
injection   Epinephrine hydrochloride   
injection   Fentanyl citrate 4,1 µg/ml
injection   Levobupivacaine hydrochloride 0,56 mg/ml
20-24°C
48 Hour
Light 3401
Level of evidence D
Not specified None 2 µg/ml
injection   Epinephrine hydrochloride   
injection   Fentanyl citrate 4,1 µg/ml
injection   Levobupivacaine hydrochloride 0,56 mg/ml
4-8°C
60 Day
Protect from light 3401
Level of evidence D
  Mentions Légales