Last update :
19/11/2024
References   References 850  
Type : Journal

Research teams : Kalamazoo - Upjohn Company, Clinical Biopharmaceutics Research
Authors : Munson J, Kubiak EJ, Cohon MS.
Title : Cytosine arabinose stability in intravenous admixtures with sodium bicarbonate and in plastic syringes.
Reference : Drug Intell Clin Pharm ; 16: 765-767. 1982

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
No visual inspection
Degradation products not observed in real conditions

List of drugs
injectionCytarabine Anticancer drug
Stability in solutions Polypropylen Syringe None 20 & 50 mg/ml -10°C Protect from light
14 Day
Stability in solutions Polypropylen Syringe None 20 & 50 mg/ml 22°C Not specified
14 Day
Stability in solutions Polypropylen Syringe None 20 & 50 mg/ml 8°C Protect from light
14 Day
injectionSodium bicarbonate Electrolyte
Stability of mixtures
Glass Glucose 5% 22°C Not specified
injection Cytarabine 0,2 & 1 mg/ml
injection Sodium bicarbonate 50 mg/ml
7 Day
Glass Glucose 5% 8°C Protect from light
injection Cytarabine 0,2 & 1 mg/ml
injection Sodium bicarbonate 50 mg/ml
7 Day
Polyvinyl chloride Glucose 5% 22°C Not specified
injection Cytarabine 0,2 & 1 mg/ml
injection Sodium bicarbonate 50 mg/ml
7 Day
Polyvinyl chloride Glucose 5% 8°C Protect from light
injection Sodium bicarbonate 50 mg/ml
injection Cytarabine 0,2 & 1 mg/ml
7 Day

  Mentions Légales