Type : |
Journal |
|
Research teams : |
Poitiers - Université de Poitiers, Faculté de Médecine et Pharmacie |
Authors : |
Rochard E, Chapelle G, Bouquet S, Barthes D, Courtois PH. |
Title : |
Stability of fluorouracil and cytarabine in ethylvinylacetate containers. |
Reference : |
J Pharm Clin ; 9: 31-35. 1989 |
|
Level of Evidence : |
|
Level of Evidence : |
![Level of evidence A Level of evidence A](./images/Picto.10612.jpg) |
Fluorouracil |
![Level of evidence B Level of evidence B](./images/Picto.10613.jpg) |
Cytarabine |
|
Physical stability : |
|
Chemical stability : |
![Thin Layer Chromatography Thin Layer Chromatography](./images/Picto.10631.jpg) | Fluorouracil | ![Stability defined as 95% of the initial concentration Stability defined as 95% of the initial concentration](./images/Picto.10659.jpg) | Fluorouracil | ![High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV) High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)](./images/Picto.10694.jpg) | Fluorouracil | ![High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV) High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)](./images/Picto.10694.jpg) | Cytarabine | ![Stability defined as 90% of the initial concentration Stability defined as 90% of the initial concentration](./images/Picto.10658.jpg) | Cytarabine |
|
Other methods : |
|
Comments : |
Degradation products identified and quantified | Fluorouracil |
|
List of drugs
Cytarabine
|
![Anticancer drug Anticancer drug](./images/Picto.486.jpg) |
![Stability in solutions Stability in solutions](./images/Picto.591.jpg) |
![Ethylene vinyl acetate Ethylene vinyl acetate](./images/Picto.539.gif) |
![NaCl 0,9% or Glucose 5% NaCl 0,9% or Glucose 5%](./images/Picto.546.gif) |
1,25 & 25 mg/ml |
25°C |
![Protect from light Protect from light](./images/Picto.526.jpg) |
28 |
![Day Day](./images/Picto.542.gif) |
|
|
![Stability in solutions Stability in solutions](./images/Picto.591.jpg) |
![Ethylene vinyl acetate Ethylene vinyl acetate](./images/Picto.539.gif) |
![NaCl 0,9% or Glucose 5% NaCl 0,9% or Glucose 5%](./images/Picto.546.gif) |
1,25 & 25 mg/ml |
35°C |
![Protect from light Protect from light](./images/Picto.526.jpg) |
14 |
![Day Day](./images/Picto.542.gif) |
|
|
![Stability in solutions Stability in solutions](./images/Picto.591.jpg) |
![Ethylene vinyl acetate Ethylene vinyl acetate](./images/Picto.539.gif) |
![NaCl 0,9% or Glucose 5% NaCl 0,9% or Glucose 5%](./images/Picto.546.gif) |
1,25 & 25 mg/ml |
4°C |
![Protect from light Protect from light](./images/Picto.526.jpg) |
28 |
![Day Day](./images/Picto.542.gif) |
|
|
|
Fluorouracil
|
![Anticancer drug Anticancer drug](./images/Picto.486.jpg) |
![Stability in solutions Stability in solutions](./images/Picto.591.jpg) |
![Ethylene vinyl acetate Ethylene vinyl acetate](./images/Picto.539.gif) |
![NaCl 0,9% or Glucose 5% NaCl 0,9% or Glucose 5%](./images/Picto.546.gif) |
10 mg/ml |
25°C |
![Protect from light Protect from light](./images/Picto.526.jpg) |
28 |
![Day Day](./images/Picto.542.gif) |
|
|
![Stability in solutions Stability in solutions](./images/Picto.591.jpg) |
![Ethylene vinyl acetate Ethylene vinyl acetate](./images/Picto.539.gif) |
![NaCl 0,9% or Glucose 5% NaCl 0,9% or Glucose 5%](./images/Picto.546.gif) |
10 mg/ml |
35°C |
![Protect from light Protect from light](./images/Picto.526.jpg) |
28 |
![Day Day](./images/Picto.542.gif) |
|
|
![Stability in solutions Stability in solutions](./images/Picto.591.jpg) |
![Ethylene vinyl acetate Ethylene vinyl acetate](./images/Picto.539.gif) |
![NaCl 0,9% or Glucose 5% NaCl 0,9% or Glucose 5%](./images/Picto.546.gif) |
10 mg/ml |
4°C |
![Protect from light Protect from light](./images/Picto.526.jpg) |
28 |
![Day Day](./images/Picto.542.gif) |
|
|
![Stability in solutions Stability in solutions](./images/Picto.591.jpg) |
![Ethylene vinyl acetate Ethylene vinyl acetate](./images/Picto.539.gif) |
![None None](./images/Picto.555.gif) |
50 mg/ml |
25°C |
![Protect from light Protect from light](./images/Picto.526.jpg) |
28 |
![Day Day](./images/Picto.542.gif) |
|
|
![Stability in solutions Stability in solutions](./images/Picto.591.jpg) |
![Ethylene vinyl acetate Ethylene vinyl acetate](./images/Picto.539.gif) |
![None None](./images/Picto.555.gif) |
50 mg/ml |
35°C |
![Protect from light Protect from light](./images/Picto.526.jpg) |
28 |
![Day Day](./images/Picto.542.gif) |
|
|
|
|