Last update :
28/04/2024
References   References 8  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/45/2/368

Research teams : Waukegan - Du pont Critical Care, Pharmaceutical Development Department
Authors : Karnatz NN, Wong J, Kesler H, Baaske DM, Speicher ER.
Title : Compatibility of esmolol hydrochloride with morphine sulfate and fentanyl citrate during simulated Y-site administration.
Reference : Am J Hosp Pharm ; 45: 368-371. 1988

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionEsmolol hydrochloride Beta-blocker
Compatible 5 mg/ml + InjectionFentanyl citrate 25 µg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + InjectionFentanyl citrate 25 µg/ml + Glucose 5%
Compatible 5 mg/ml + InjectionMorphine sulfate 7,5 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + InjectionMorphine sulfate 7,5 mg/ml + Glucose 5%
InjectionFentanyl citrate Analgesic
Compatible 25 µg/ml + InjectionEsmolol hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 25 µg/ml + InjectionEsmolol hydrochloride 5 mg/ml + Glucose 5%
InjectionMorphine sulfate Analgesic
Compatible 7,5 mg/ml + InjectionEsmolol hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 7,5 mg/ml + InjectionEsmolol hydrochloride 5 mg/ml + Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 15°C-30°C Light
Injection Esmolol hydrochloride 5 mg/ml
Injection Morphine sulfate 7,5 mg/ml
8 Hour
Glass NaCl 0,9% or Glucose 5% 15°C-30°C Light
Injection Esmolol hydrochloride 5 mg/ml
Injection Fentanyl citrate 25 µg/ml
8 Hour

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