Last update :
18/07/2024
References   References 738  
Type : Journal

Research teams : Mount Prospect - Arnar-Stone laboratories
Authors : Gardella LA, Kesler H, Amann A, Carter JE.
Title : Intropin (dopamine hydrochloride) intravenous admixture compatibility. Part 3: Stability with miscellaneous additives.
Reference : Am J Hosp Pharm ; 35: 581-584. 1978

Level of Evidence : 
Joker
Level of Evidence : 
Biological analysis
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
Thin Layer Chromatography
Gas chromatography
Other methods : 
PH measurement 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
injectionCalcium chloride Electrolyte
Compatible + injectionDopamine hydrochloride 0.8 mg/ml + Glucose 5%
injectionCefalotin sodium Antibiotic
Compatible 4 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 0.8 mg/ml + injectionCalcium chloride + Glucose 5%
Compatible 0.8 mg/ml + injectionCefalotin sodium 4 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionGentamicin sulfate 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionHeparin sodium 200 UI/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionHydrocortisone sodium succinate 1 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionLidocaine hydrochloride 4 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionMethylprednisolone sodium succinate 0.5 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionOxacillin sodium 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionPotassium chloride + Glucose 5%
injectionGentamicin sulfate Antibiotic
Compatible 2 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 200 UI/ml + injectionDopamine hydrochloride 0.8 mg/ml + Glucose 5%
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + Glucose 5%
injectionLidocaine hydrochloride Local anesthetic
Compatible 4 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + Glucose 5%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 0.5 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + Glucose 5%
injectionOxacillin sodium Antibiotic
Compatible 2 mg/ml + injectionDopamine hydrochloride 0.8 mg/ml + Glucose 5%
injectionPotassium chloride Electrolyte
Compatible + injectionDopamine hydrochloride 0.8 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 23°C-25°C Light
injection Dopamine hydrochloride 0,8 mg/ml
injection Heparin sodium 20 UI/ml
24 Hour
Glass Glucose 5% 23°C-25°C Light
injection Dopamine hydrochloride 0,8 mg/ml
injection Lidocaine hydrochloride 3,26 mg/ml
24 Hour
Glass Glucose 5% 23°C-25°C Light
injection Dopamine hydrochloride 0,8 mg/ml
injection Cefalotin sodium 4 mg/ml
24 Hour
Glass Glucose 5% 23°C-25°C Light
injection Dopamine hydrochloride 0,8 mg/ml
injection Oxacillin sodium 2 mg/ml
24 Hour
Glass Glucose 5% 23°C-25°C Light
injection Dopamine hydrochloride 0,8 mg/ml
injection Gentamicin sulfate 0,32 mg/ml
24 Hour

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