Last update :
18/04/2024
References   References 693  
Type : Journal

Research teams : Houston - University of Houston, College of Pharmacy
Authors : Das Gupta V, Parasrampuria J, Bethea C.
Title : Chemical stabilities of famotidine and ranitidine hydrochloride in intravenous admixtures.
Reference : J Clin Pharm Ther ; 13: 329-334. 1988

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
InjectionFamotidine Antihistamine (H2)
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,2 mg/ml 25°C Not specified
15 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,2 mg/ml 4°C Protect from light
63 Day
InjectionRanitidine hydrochloride Antihistamine (H2)
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 mg/ml 25°C Not specified
15 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 1 mg/ml 5°C Protect from light
63 Day

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