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References   References 53  
Type : Journal
Research teams : Kansas City - University of Kansas Medical center, Department of Pediatrics
Authors : Henry DW, Marshall JL, Nazzar OD, Fox JL, Leff RD.
Title : Stability of cisplatin and ondansetron hydrochloride in admixtures for continuous infusion.
Reference : Am J Health-Syst Pharm ; 52: 2570-2573. 1995
Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No comments for the degradation products
List of drugs
InjectionCisplatin Anticancer drug
Compatible 0,455 mg/ml + InjectionOndansetron hydrochloride 1,091 mg/ml + Sodium chloride 0,9%
Compatible 0,2 mg/ml + InjectionOndansetron hydrochloride 0,48 mg/ml + Sodium chloride 0,9%
InjectionOndansetron hydrochloride Antiemetic
Compatible 1,091 mg/ml + InjectionCisplatin 0,455 mg/ml + Sodium chloride 0,9%
Compatible 0,48 mg/ml + InjectionCisplatin 0,2 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 2-8°C Protect from light
Injection Cisplatin 0,455 mg/ml
Injection Ondansetron hydrochloride 1,091 mg/ml
24 Hour
Polyvinyl chloride Sodium chloride 0,9% 30°C Protect from light
Injection Cisplatin 0,455 mg/ml
Injection Ondansetron hydrochloride 1,091 mg/ml
168 Hour
  Mentions Légales