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References   References 5095  
Type : Journal
Web link : https://doi.org/10.2147/DDDT.S543730
Research teams : Barcelona - Hopital Clinic of Barcelona
Authors : Lopez-Cabezas C, Baguena J, Briansó M.M, Gotor G, Ceamanos S, Cuñat T, Broto-Puig F, Soy D.
Title : Compatibility and Physico-Chemical Stability of Six Intravenous Mixtures for Postoperative Multimodal Analgesia.
Reference : Drug Design Dev Ther ; 9 8041–8048. 2025
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
List of drugs
injectionDexketoprofen Anti-inflammatory
injectionKetamine hydrochloride General anesthetic
injectionKetorolac tromethamine Anti-inflammatory
injectionMethadone hydrochloride Analgesic
Factors which affect stability Container Silicone elastomer Induces Adsorption
Factors which affect stability Container Polyisoprene elastomer Induces Adsorption
injectionTramadol hydrochloride Analgesic
Stability of mixtures
Polyolefine Sodium chloride 0,9% 2-8°C Protect from light
injection Tramadol hydrochloride 7,5 mg/ml
injection Dexketoprofen 2,26 mg/ml
injection Ketamine hydrochloride 0,19 mg/ml
30 Day
Polyolefine Sodium chloride 0,9% 2-8°C Protect from light
injection Tramadol hydrochloride 7,5 mg/ml
injection Dexketoprofen 2,26 mg/ml
injection Ketamine hydrochloride 0,19 mg/ml
injection Methadone hydrochloride 0,075 mg/ml
30 Day
Polyolefine Sodium chloride 0,9% 2-8°C Protect from light
injection Tramadol hydrochloride 7,9 mg/ml
injection Ketorolac tromethamine 0,95 mg/ml
injection Ketamine hydrochloride 0,95 mg/ml
injection Methadone hydrochloride 0,08 mg/ml
30 Day
Polyolefine Sodium chloride 0,9% 2-8°C Protect from light
injection Tramadol hydrochloride 7,9 mg/ml
injection Ketorolac tromethamine 0,95 mg/ml
injection Ketamine hydrochloride 0,95 mg/ml
30 Day
Polyolefine Sodium chloride 0,9% 20-25°C Protect from light
injection Tramadol hydrochloride 7,5 mg/ml
injection Dexketoprofen 2,26 mg/ml
injection Ketamine hydrochloride 0,19 mg/ml
48 Hour
Polyolefine Sodium chloride 0,9% 20-25°C Protect from light
injection Tramadol hydrochloride 7,5 mg/ml
injection Dexketoprofen 2,26 mg/ml
injection Ketamine hydrochloride 0,19 mg/ml
injection Methadone hydrochloride 0,075 mg/ml
48 Hour
Polyolefine Sodium chloride 0,9% 20-25°C Protect from light
injection Tramadol hydrochloride 7,9 mg/ml
injection Ketorolac tromethamine 0,95 mg/ml
injection Ketamine hydrochloride 0,95 mg/ml
injection Methadone hydrochloride 0,08 mg/ml
48 Hour
Polyolefine Sodium chloride 0,9% 20-25°C Protect from light
injection Tramadol hydrochloride 7,9 mg/ml
injection Ketorolac tromethamine 0,95 mg/ml
injection Ketamine hydrochloride 0,95 mg/ml
48 Hour
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